Asenapine Maleate | CAS No. 85650-56-2

Q: What is Asenapine Maleate (CAS: 85650-56-2)?

Asenapine Maleate is a pharmaceutical compound used primarily as an antipsychotic medication. It has the chemical formula C22H25NO3·C4H4O4 and is known for its stability and solubility properties. This compound is commonly used in the treatment of schizophrenia and bipolar disorder due to its ability to modulate dopamine and serotonin receptors.

Q: What are the main uses of Asenapine Maleate (CAS: 85650-56-2)?

Asenapine Maleate is mainly used in pharmaceutical applications as a treatment for schizophrenia and bipolar disorder. It is also used in research for studying its pharmacological effects and mechanisms. Due to its chemical stability, it may find use in drug formulation and development processes.

Q: Is Asenapine Maleate (CAS: 85650-56-2) safe?

Asenapine Maleate is considered safe when used as directed in medical treatment. It has been evaluated for toxicity and is generally well-tolerated. However, proper handling and storage are necessary to maintain its efficacy and safety. Protective measures such as gloves and proper ventilation should be used during handling to minimize exposure.

Q: How should Asenapine Maleate (CAS: 85650-56-2) be stored?

Asenapine Maleate should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 25°C and should be protected from moisture. Storage in airtight containers is recommended to ensure stability and prevent degradation over time.

Asenapine Maleate

Basic Information

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CAS Number

85650-56-2

Molecular Formula

C21H20ClNO5

Molecular Weight

401.85 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

No data available

Melting Point

141-145°

Boiling Point

357.9°C at 760 mmHg

Density

1.83X10-6 mm Hg at 25 deg C (est)

Solubility

H2O: ≥10mg/mL

Refractive Index

1.609

Vapor Pressure

No data available

SMILES

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CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=CC(=O)O)C(=O)O

InChI

InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)

InChIKey

GMDCDXMAFMEDAG-UHFFFAOYSA-N

LogP

3.9703000000000026

pKa

pK1 <3, pK2 7.52, pK3 8.51(at 25℃)

Topological Polar Surface Area

87.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

482

Safety Information

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GHS Hazard Pictograms

H301

H315

H319

H335

H400

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Synonyms & References

English

Org 5222
CHEBI:71245
(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(18),7,9,11,14,16-hexaene; (2Z)-but-2-enedioic acid
Saphris
ASENAPINE MALEATE [JAN]
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
Org-5222
CCG-268667
1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-,(3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
ASENAPINE MALEATE [WHO-DD]
NS00092977
ASENAPINE MALEATE [ORANGE BOOK]
trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrolemaleate
AC-24116
135883-08-8
Asenapine maleate
SCHEMBL175228
ASENAPINE MALEATE (MART.)
SW219879-1
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole monomaleate
85650-56-2
s1283
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole (2Z)-2-butenedioate
65576-45-6, 135883-08-8 (Maleic acid)
Asenapine maleate [USAN]
1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-,(3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
AKOS015951084
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrol-2-ium (2Z)-3-prop-2-enoate
1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole (2Z)-but-2-enedioate
Asenapine maleate (JAN/USAN)

MDL Number

MFCD00900588

FAQ

What is Asenapine Maleate (CAS: 85650-56-2)?

Asenapine Maleate is a pharmaceutical compound used primarily as an antipsychotic medication. It has the chemical formula C22H25NO3·C4H4O4 and is known for its stability and solubility properties. This compound is commonly used in the treatment of schizophrenia and bipolar disorder due to its ability to modulate dopamine and serotonin receptors.

What are the main uses of Asenapine Maleate (CAS: 85650-56-2)?

Asenapine Maleate is mainly used in pharmaceutical applications as a treatment for schizophrenia and bipolar disorder. It is also used in research for studying its pharmacological effects and mechanisms. Due to its chemical stability, it may find use in drug formulation and development processes.

Is Asenapine Maleate (CAS: 85650-56-2) safe?

Asenapine Maleate is considered safe when used as directed in medical treatment. It has been evaluated for toxicity and is generally well-tolerated. However, proper handling and storage are necessary to maintain its efficacy and safety. Protective measures such as gloves and proper ventilation should be used during handling to minimize exposure.

How should Asenapine Maleate (CAS: 85650-56-2) be stored?

Asenapine Maleate should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 25°C and should be protected from moisture. Storage in airtight containers is recommended to ensure stability and prevent degradation over time.