6-Bromo-4-nitro-1H-indazole(CAS: 885518-46-7)

6-Bromo-4-nitro-1H-indazole (CAS: 885518-46-7) is a crystalline solid with a molecular weight of approximately 267.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound is known for its high reactivity, particularly with reducing agents and nucleophiles. It exhibits typical amphoteric behavior, reacting both as an acid and a base under certain conditions.

6-Bromo-4-nitro-1H-indazole (CAS: 885518-46-7) is typically synthesized through nitration of indazole followed by bromination. Common methods involve using concentrated nitric acid (HNO3) and sulfuric acid (H2SO4) as the nitration reagents, followed by bromination using bromine (Br2) in the presence of a base like potassium hydroxide (KOH). The reaction is carried out under carefully controlled conditions to achieve high yield and selectivity.

6-Bromo-4-nitro-1H-indazole (CAS: 885518-46-7) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various medicinal compounds, particularly those involving aromatic substitution reactions. Its applications include the development of new drugs, sensors, and materials for electronic devices.

When handling 6-Bromo-4-nitro-1H-indazole (CAS: 885518-46-7), it is essential to use personal protective equipment (PPE) including safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.