4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone

Basic Information

View in Editor

CAS Number

58-97-9

Molecular Formula

C9H13N2O9P

Molecular Weight

324.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Boiling Point

700.1±70.0 °C at 760 mmHg

Flash Point

377.2±35.7 °C

Solubility

H2O: soluble50mg/mL, clear, colorless

SMILES

View in Editor

C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O

InChI

InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChIKey

DJJCXFVJDGTHFX-XVFCMESISA-N

LogP

-2.7348999999999983

Topological Polar Surface Area

171.30999999999997 Å²

Hydrogen Bond Donor/Acceptor

5 / 11

Complexity

517

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

NCGC00163325-01
uridine-5'-phosphate
Uridine mono(dihydrogen phosphate)
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
DB03685
uridylate
5'-Monophosphate, Uridine
MFCD00067346
CHEMBL214393
U 5'-P
C00105
5-24-06-00173 (Beilstein Handbook Reference)
Acid, Uridylic
[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
AC-32138
Q27074278
Uridine phosphate
Uridine 5'-monophosphate
E2OU15WN0N
DTXSID20883211
UridylsA currencyure
Uridine monophosphate
27416-86-0
AKOS016009839
5'Uridylic acid
uridine-monophosphate
5'-URIDYLIC ACID [MI]
Uridylic acid
((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
1xz8
5'-Uridylate monophosphate

MDL Number

MFCD00067346

Customs Code

2934999090

FAQ

What is 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9)?

4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9) is a nucleoside analog with a pyrimidinone ring linked to a ribose sugar via a phosphono group. Its chemical formula is C8H11N2O7P. It is commonly used as a key intermediate in the synthesis of nucleotides and nucleosides, exhibiting stability under controlled conditions and specific reactivity due to its phosphate functionality.

What are the main uses of 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9)?

This compound is primarily utilized in pharmaceuticals as a precursor for developing antiviral and anticancer drugs. It also serves as an industrial chemical intermediate and is relevant in research for studying nucleotide metabolism. Additionally, it may be applied in food science for flavor or nutritional purposes, depending on regulatory approvals.

Is 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9) safe?

Safety of 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9) depends on handling and exposure. While it is generally considered safe in controlled environments, proper protective measures such as gloves and ventilation are recommended. Regulatory guidelines emphasize adherence to standard chemical safety protocols to minimize risks during industrial or research use.

How should 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9) be stored?

Store 4-Hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-2(1H)-pyrimidinone (CAS: 58-97-9) in a cool, dry place (2-8°C), away from moisture and light. Use airtight, dark-colored containers to maintain stability and prevent degradation. Ensure proper labeling and secure storage to avoid contamination or accidental exposure.