Pictilisib Bismesylate

Basic Information

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CAS Number

957054-33-0

Molecular Formula

C25H35N7O9S4

Molecular Weight

705.85 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>280°C (dec.)

SMILES

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CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6.CS(=O)(=O)O.CS(=O)(=O)O

InChI

InChI=1S/C23H27N7O3S2.2CH4O3S/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19;2*1-5(2,3)4/h2-4,13-14H,5-12,15H2,1H3,(H,24,27);2*1H3,(H,2,3,4)

InChIKey

RFRIKACSFOTIMU-UHFFFAOYSA-N

LogP

1.1564000000000032

Topological Polar Surface Area

216.28999999999996 Å²

Hydrogen Bond Donor/Acceptor

3 / 16

Complexity

924

Synonyms & References

English

C25H35N7O9S4
4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine dimethanesulfonate
GDC-0941 Bimesylate
GDC 0941 BISMESYLATE
GDC0941
GDC-0941
GDC-0941 bismesylate
GDC-0941 (2 MeSO3H salt)
GDC0941 dimethanesulfonate
Pictilisib
Pictilisib dimethanesulfonate
GDC-0941 dimethanesulfonate
G3D7HF2GS9
HY-20180
MS-31183
GDC 0941 bismesylate
DS-016785
UNII-G3D7HF2GS9
E98860
4-{6-[(4-methanesulfonylpiperazin-1-yl)methyl]-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-2-yl}-2H-indazole; bis(methanesulfonic acid)
GDC-0941 (dimethanesulfonate) ;GDC-0941 (2 MeSO3H salt)
AKOS028108233
Pictilisib dimesylate
957054-33-0
BCP13802
CHEMBL4097197
Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-, methanesulfonate (1:2)
GDC 0941 bimesylate
4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morph
4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;methanesulfonic acid
GDC-0941 bimesylate salt, Pictilisib dimethanesulfonate

MDL Number

MFCD12546329

FAQ

What is Pictilisib Bismesylate (CAS: 957054-33-0)?

Pictilisib Bismesylate (CAS: 957054-33-0) is a chemical compound used in pharmaceutical research and development, particularly as an inhibitor of phosphoinositide 3-kinase (PI3K) pathways. It is a bismesylate salt of pictilisib, a small molecule that targets PI3Kalpha, PI3Kbeta, and PI3Kdelta. The compound is used in the development of potential therapeutics for various diseases, including cancer and autoimmune disorders.

What are the main uses of Pictilisib Bismesylate (CAS: 957054-33-0)?

Pictilisib Bismesylate (CAS: 957054-33-0) is primarily used in pharmaceutical research to investigate and develop drugs targeting the PI3K pathway. It is a key compound in the development of cancer treatments and has potential applications in autoimmune disorders. These uses are based on its ability to inhibit PI3Kalpha, PI3Kbeta, and PI3Kdelta, making it a valuable tool in therapeutic drug discovery.

Is Pictilisib Bismesylate (CAS: 957054-33-0) safe?

Pictilisib Bismesylate (CAS: 957054-33-0) is generally considered safe when used under the guidance of a trained professional. However, it is important to follow all safety precautions, including wearing appropriate personal protective equipment (PPE) such as gloves and goggles. This compound should be handled in a well-ventilated area and stored away from heat and direct sunlight. Immediate medical attention may be required if ingestion or exposure occurs.

How should Pictilisib Bismesylate (CAS: 957054-33-0) be stored?

Pictilisib Bismesylate (CAS: 957054-33-0) should be stored at room temperature (15-30°C), away from direct sunlight and heat sources. It should be kept in a cool, dry place and stored in a tightly closed container to prevent degradation. The compound should be protected from moisture and excessive humidity. It is recommended to store it in a secure, locked cabinet to prevent unauthorized access. Always refer to the Material Safety Data Sheet (MSDS) for specific storage instructions and safety information.