8-Fluoroquinoline

Basic Information

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CAS Number

394-68-3

Molecular Formula

C9H6FN

Molecular Weight

147.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

148°C/30mmHg

Density

1.216

Flash Point

98 °C

Refractive Index

1.614

SMILES

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C1=CC2=C(C(=C1)F)N=CC=C2

InChI

InChI=1S/C9H6FN/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H

InChIKey

RNAAXKYOTPSFGV-UHFFFAOYSA-N

LogP

2.3739

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

138

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

8-Fluoroquinoline
Quinoline, 8-fluoro-
A824560
FLUOROQUINOLINE, 8-
CCRIS 2891
AC-3295
W-200551
PS-6513
NSC 51786
SB67539
CHEMBL1162366
8-Fluoroquinoline, AldrichCPR
RNAAXKYOTPSFGV-UHFFFAOYSA-N
EN300-27706
CS-W001560
AKOS005259248
394-68-3
R)-(+)-methyl(R)-2-chloropropionate
NSC-51786
F1185
Z243277338
SCHEMBL1538341
NS00125050
UNII-WC3ZS5FY7R
BRN 0114548
FT-0658639
SY004608
NSC51786
MFCD01685514
8-Fluoro-quinolinium
WC3ZS5FY7R

MDL Number

MFCD01685514

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 8-Fluoroquinoline (CAS: 394-68-3)?

8-Fluoroquinoline is a crystalline compound with a molecular weight of approximately 158.06 g/mol. It has a solubility of about 100 mg/L in water and is slightly soluble in ethanol. Chemically, it is moderately reactive, particularly with bases and reducing agents. It is stable under normal storage conditions but should be kept away from strong oxidizing agents.

How is 8-Fluoroquinoline (CAS: 394-68-3) typically synthesized?

8-Fluoroquinoline is commonly synthesized through the fluorination of quinoline or its derivatives. This process often involves using fluoroamine or other fluorinating agents under basic conditions. The yield is generally good, around 70-80%, and the method is selective for the fluorination of the quinoline ring.

What industries use 8-Fluoroquinoline (CAS: 394-68-3)?

8-Fluoroquinoline is primarily used in the pharmaceutical industry for the development of anti-inflammatory and antiviral drugs. It is also used in the synthesis of organic semiconductors and as a precursor in the polymer industry for the production of advanced materials with specific electronic properties. Additionally, it has applications in sensor technology.

What precautions should be taken when handling 8-Fluoroquinoline (CAS: 394-68-3)?

When handling 8-fluoroquinoline, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a sealed container away from incompatible materials, especially strong oxidizing agents. Spills should be cleaned up using appropriate procedures, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.