N-Fmoc-L-alanine Hydrate

Basic Information

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CAS Number

207291-76-7

Molecular Formula

C18H19NO5

Molecular Weight

329.35 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

155-158 °C

Water Solubility

Insoluble in water.

SMILES

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C[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O.[H]O[H]

InChI

InChI=1S/C18H17NO4.H2O/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16;/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21);1H2/t11-;/m0./s1

InChIKey

GAPWKFLOMOFHGO-MERQFXBCSA-N

LogP

2.1735000000000007

Topological Polar Surface Area

107.13 Å²

Hydrogen Bond Donor/Acceptor

4 / 6

Complexity

430

Synonyms & References

English

Fmoc-L-Alanine monohydrate
N-Fmoc-L-alanine monohydrate
Fmoc-Ala hydrate
Fmoc-L-Alanine hydrate
N-Fmoc-L-alanine
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid hydrate

MDL Number

MFCD00150487

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7)?

N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7) is a crystalline compound with a molecular weight of approximately 250.24 g/mol. It has a solubility of about 1.5 g/L in water. This compound is moderately reactive and can undergo hydrolysis under acidic or basic conditions. It is used in peptide synthesis due to its ability to form stable esters.

How is N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7) typically synthesized?

N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7) is typically synthesized by coupling Fmoc-L-alanine with a suitable coupling reagent like HATU or DIC/HzOAc in the presence of a base such as DIPEA. The reaction yields a hydrate form, which is purified by recrystallization from water or a suitable solvent.

What industries use N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7)?

N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7) is primarily used in the pharmaceutical industry for the synthesis of peptidomimetics and drugs. It is also employed in the polymer industry for making functional polymers and in the sensor industry for developing biosensors.

What precautions should be taken when handling N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7)?

When handling N-Fmoc-L-alanine Hydrate (CAS: 207291-76-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Store it in a cool, dry place away from direct sunlight and moisture. In case of spill, avoid inhaling dust and use a fume hood. Refer to the safety data sheet (SDS) for detailed emergency procedures.