7-Chloro-1,3-dihydro-2H-indol-2-one

Basic Information

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CAS Number

25369-33-9

Molecular Formula

C8H6ClNO

Molecular Weight

167.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

221-225 °C

Boiling Point

341°C at 760 mmHg

Density

1.362

Flash Point

164.5 °C

Refractive Index

1.601

SMILES

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C1C2=C(C(=CC=C2)Cl)NC1=O

InChI

InChI=1S/C8H6ClNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11)

InChIKey

FPDLUAACCNVSQA-UHFFFAOYSA-N

LogP

1.8345999999999998

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

183

Safety Information

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GHS Hazard Pictograms

H302

H319

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AC-22699
Q-102632
CHEMBL2381488
7-Chlorooxindole
AB25436
FPDLUAACCNVSQA-UHFFFAOYSA-N
2H-Indol-2-one,7-chloro-1,3-dihydro-
AMY3655
FT-0656933
7-chloroindolin-2-one
BDBM50434117
7-Chloro-1,3-dihydro-2H-indol-2-one
AS-32983
7-chlor-oindolin-2-one
7-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
7-chloro-1,3-dihydroindol-2-one
25369-33-9
SCHEMBL1162926
MFCD06656001
SY029305
7-Chloro-2-oxindole, 97%
7-Chloro-2-oxindole
AKOS005258603
DTXSID301293540
CS-W008306
7-Chloroindolin-2-one
5-Chloro-1,3-dihydro-2H-indol-2-one
7023 7-CHLOROINDOLIN-2-ONE
7-CHLOROOXINDOLE
7-Chloro-2-oxyindole
2H-Indol-2-one, 7-chloro-1,3-dihydro-

MDL Number

MFCD06656001

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 7-Chloro-1,3-dihydro-2H-indol-2-one (CAS: 25369-33-9)?

7-Chloro-1,3-dihydro-2H-indol-2-one is a solid with a white to off-white crystalline form. Its molecular weight is approximately 223.67 g/mol. The compound has limited water solubility and excellent solubility in organic solvents like dichloromethane and acetonitrile. It is moderately reactive towards nucleophiles and is known to undergo electrophilic aromatic substitution reactions.

How is 7-Chloro-1,3-dihydro-2H-indol-2-one (CAS: 25369-33-9) typically synthesized?

7-Chloro-1,3-dihydro-2H-indol-2-one can be synthesized through the condensation of 2-chloroacetophenone with indole. The reaction requires a base like sodium hydroxide and is carried out in a solvent such as water or methanol. The yield is typically around 70-80%, and the reaction is selective towards the formation of the 2-hydroxy-3-chloroacetophenone intermediate which then cyclizes to form the target compound.

What industries use 7-Chloro-1,3-dihydro-2H-indol-2-one (CAS: 25369-33-9)?

7-Chloro-1,3-dihydro-2H-indol-2-one is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties. In polymers, it serves as a functional monomer with potential for introducing specific functionalities.

What precautions should be taken when handling 7-Chloro-1,3-dihydro-2H-indol-2-one (CAS: 25369-33-9)?

When handling 7-Chloro-1,3-dihydro-2H-indol-2-one, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be immediately cleaned up and disposed of according to safety data sheet (SDS) guidelines. Always consult the SDS for detailed safety information.