2,4-Dichloro-5-fluorobenzoyl chloride(CAS: 86393-34-2)

2,4-Dichloro-5-fluorobenzoyl chloride is a white crystalline solid with a molecular weight of approximately 261.04 g/mol. It has a low water solubility but is soluble in common organic solvents like dichloromethane and acetonitrile. This compound is highly reactive, particularly towards nucleophiles, and is often used in synthetic reactions requiring electrophilic aromatic substitution.

2,4-Dichloro-5-fluorobenzoyl chloride is typically synthesized by the reaction of 2,4-dichloro-5-fluorobenzoic acid with thionyl chloride in the presence of a suitable catalyst, such as aluminum chloride. The reaction yields high selectivity and good to excellent purity, with a yield ranging from 70% to 90%.

2,4-Dichloro-5-fluorobenzoyl chloride is used in the pharmaceutical, polymer, and analytical chemistry industries. It serves as a key intermediate in the synthesis of various organic compounds, including drugs and materials for sensors and semiconductors.

When handling 2,4-Dichloro-5-fluorobenzoyl chloride, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up with care, and the site should be decontaminated using water and appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and handling instructions.