2-(Trifluoromethoxy)phenol

Basic Information

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CAS Number

32858-93-8

Molecular Formula

C7H5F3O2

Molecular Weight

178.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

40-45°C

Boiling Point

156.8°C at 760 mmHg

Flash Point

47°C

Refractive Index

1.443

SMILES

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C1=CC=C(C(=C1)O)OC(F)(F)F

InChI

InChI=1S/C7H5F3O2/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4,11H

InChIKey

GQWMNVOVQZIPJC-UHFFFAOYSA-N

LogP

2.2908

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

146

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Sensitive to air

Synonyms & References

English

2-(Trifluorormethoxy)phenol
SY020774
2-trifluoromethoxy-phenol
GQWMNVOVQZIPJC-UHFFFAOYSA-
CS-W017348
AKOS005257929
O10542
FT-0608931
2-(Trifluoromethoxy)phenol
2,2,3,3-TETRAMETHYLSUCCINICACID,97
T2156
BCP27397
2-Hydroxyphenyl Trifluoromethyl Ether
EN300-133018
o-trifluoromethoxy phenol
2-(trifluormethoxy)phenol
PS-8564
32858-93-8
trifluoromethoxyphenol
O-TRIFLUOROMETHOXYPHENOL
2-Hydroxyphenyl Trifluoromethyl Ether;O-trifluoromethoxy phenol
BP-11107
Phenol, 2-(trifluoromethoxy)-
SCHEMBL225016
2-(trifluoromethyloxy)phenol
Trifluoromethoxy phenol
AM20050275
2-trifluoromethoxyphenol
2-trifluoromethoxy phenol
DTXSID70380462
AC-17472

MDL Number

MFCD00236324

Customs Code

2909500000

FAQ

What regulatory guidelines apply to 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8)?

2-(Trifluoromethoxy)phenol (CAS: 32858-93-8) is classified under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) as a skin and eye irritant and toxic to aquatic life. It is also subject to the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulations in the European Union, which require manufacturers and importers to register substances above a certain tonnage threshold. In the United States, FDA and EPA regulations may also apply, including reporting of releases and environmental releases under the Toxic Substances Control Act (TSCA).

Are there alternatives to 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8) in synthesis?

In the synthesis of derivatives similar to 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8), alternatives such as 4-(trifluoromethoxy)phenol or other substituted phenols may be used depending on the desired properties. Common alternative reagents include trifluoromethoxybenzyl triflate or other trifluoromethoxy-protected intermediates, which can offer comparable functionality with different handling properties.

What is the market or research trend for 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8)?

The market for 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8) is growing due to its use as a key intermediate in the synthesis of pharmaceuticals and agrochemicals where its unique trifluoromethoxy group provides specific biological activities. Research trends focus on its application in drug discovery and development, particularly in areas targeting inflammation and cancer. Additionally, there is increasing interest in developing more sustainable and environmentally friendly synthetic routes and waste management strategies for this compound.

How should waste containing 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8) be handled?

Waste containing 2-(Trifluoromethoxy)phenol (CAS: 32858-93-8) should be collected in sealed, leak-proof containers and stored in a secure area away from sources of ignition and incompatible materials. Incineration is a common method for disposal, provided it meets local environmental regulations. Alternatively, professional waste disposal services equipped with appropriate technology for handling hazardous chemicals can be employed. Proper labeling and documentation of waste generation are essential to ensure compliance with regulatory requirements.