2-Fluoropyridine

Basic Information

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CAS Number

372-48-5

Molecular Formula

C5H4FN

Molecular Weight

97.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

126°C

Water Solubility

Soluble in water.

Refractive Index

n20/D 1.466(lit.)

SMILES

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C1=CC=NC(=C1)F

InChI

InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H

InChIKey

MTAODLNXWYIKSO-UHFFFAOYSA-N

LogP

1.2207

pKa

-0.44(at 25℃)

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

Safety Information

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Hazard Statement

Hazard Class

Class 3 Class 3

Synonyms & References

English

2-Fluoropyridine #
5-20-05-00397 (Beilstein Handbook Reference)
2-Fluoropyridine
F0001-1073
fluoropyridine
CHEMBL1162360
WKQ4JPY48S
DTXSID70190689
AC-7018
2Fluoropyridine
A823583
Pyridine, fluoro-
InChI=1/C5H4FN/c6-5-3-1-2-4-7-5/h1-4
CCRIS 1725
2-Pyridyl fluoride
NSC5077
EINECS 206-757-5
AKOS000119365
NSC-5077
FT-0602552
SB52269
F0217
W-106553
UNII-WKQ4JPY48S
BRN 0001515
NS00042189
BP-13083
P16538
CS-W011339
AI3-28562
2-Fluoropyridine, 98%

MDL Number

MFCD00006224

Customs Code

2933399090

FAQ

What is 2-Fluoropyridine (CAS: 372-48-5)?

2-Fluoropyridine (CAS: 372-48-5) is a heterocyclic aromatic compound with the molecular formula C5H4FN. It features a pyridine ring substituted with a fluorine atom at the 2-position, exhibiting properties such as moderate solubility in polar solvents and a melting point of 56-58°C. This compound is commonly used as an intermediate in organic synthesis due to its reactivity and functional group versatility.

What are the main uses of 2-Fluoropyridine (CAS: 372-48-5)?

2-Fluoropyridine (CAS: 372-48-5) is primarily utilized in pharmaceuticals as a building block for drug development, including antifungal and antiviral agents. It also serves industrial applications in agrochemicals and materials science. Additionally, it is employed in research for synthesizing fluorinated derivatives and studying chemical reactivity, owing to its unique electronic properties and stability.

Is 2-Fluoropyridine (CAS: 372-48-5) safe?

2-Fluoropyridine (CAS: 372-48-5) requires careful handling due to its potential toxicity. It may cause skin and eye irritation, and inhalation should be avoided. Safety standards recommend working in a well-ventilated area, using protective gloves and goggles, and following OSHA guidelines. Proper storage and handling are essential to minimize health and environmental risks.

How should 2-Fluoropyridine (CAS: 372-48-5) be stored?

2-Fluoropyridine (CAS: 372-48-5) should be stored in a cool, dry place (ideally 2-8°C), away from light and moisture. It is best kept in sealed, airtight containers made of glass or inert material to prevent degradation. Avoid exposure to incompatible substances and ensure storage areas are well-ventilated to maintain stability and safety.