2,4-Dichloro-5-fluorobenzoyl chloride

Basic Information

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CAS Number

86393-34-2

Molecular Formula

C7H2Cl3FO

Molecular Weight

227.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

143-144 ºC (35 mmHg)

Density

1.568

Flash Point

>110 ºC

Refractive Index

1.572

SMILES

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Fc1cc(C(=O)Cl)c(Cl)cc1Cl

InChI

InChI=1S/C7H2Cl3FO/c8-4-2-5(9)6(11)1-3(4)7(10)12/h1-2H

InChIKey

RPZXUSJCSDQNTE-UHFFFAOYSA-N

LogP

3.5115000000000007

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

188

Safety Information

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Hazard Statement

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H412 Harmful to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

2,4-dichloro-5-fluorobenzoyl chloride
2,4-Dichloro-5-Fluorosbenzoylchloride
2,4-dichloro-5-fluorobenzoic acid chloride
2,4-dichloro-5-fluoro-benzoyl chloride
2,4-Dichloro-5-fluorobenzoylchloride
2,4-dichloro-5-fluoro benzoyl chloride
2,4-Dichlor-5-fluor-benzoylchlorid
Benzoyl chloride,2,4-dichloro-5-fluoro-
RPZXUSJCSDQNTE-UHFFFAOYSA-N
PC3408
SBB067910
AS00060
VZ22506
FCH1321900
CM12645
D4380
2,4-Dichloro-5-fluorobenzoyl chlorid

MDL Number

MFCD00075341

Customs Code

2916399090

FAQ

What are the physical and chemical properties of 2,4-Dichloro-5-fluorobenzoyl chloride (CAS: 86393-34-2)?

2,4-Dichloro-5-fluorobenzoyl chloride is a white crystalline solid with a molecular weight of approximately 261.04 g/mol. It has a low water solubility but is soluble in common organic solvents like dichloromethane and acetonitrile. This compound is highly reactive, particularly towards nucleophiles, and is often used in synthetic reactions requiring electrophilic aromatic substitution.

How is 2,4-Dichloro-5-fluorobenzoyl chloride (CAS: 86393-34-2) typically synthesized?

2,4-Dichloro-5-fluorobenzoyl chloride is typically synthesized by the reaction of 2,4-dichloro-5-fluorobenzoic acid with thionyl chloride in the presence of a suitable catalyst, such as aluminum chloride. The reaction yields high selectivity and good to excellent purity, with a yield ranging from 70% to 90%.

What industries use 2,4-Dichloro-5-fluorobenzoyl chloride (CAS: 86393-34-2)?

2,4-Dichloro-5-fluorobenzoyl chloride is used in the pharmaceutical, polymer, and analytical chemistry industries. It serves as a key intermediate in the synthesis of various organic compounds, including drugs and materials for sensors and semiconductors.

What precautions should be taken when handling 2,4-Dichloro-5-fluorobenzoyl chloride (CAS: 86393-34-2)?

When handling 2,4-Dichloro-5-fluorobenzoyl chloride, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up with care, and the site should be decontaminated using water and appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and handling instructions.