2-(4,4-Difluorobutyl)-1H-isoindole-1,3(2H)-dione
CAS Number:
1265341-14-7
Molecular Formula:
C12H11F2NO2
Photoinduced defluorinative alkylation of trifluoromethyl alkenes with carbonyl derivatives by C–C bond scission
Literature Information
Publication Date
2023-11-07
DOI
10.1039/D3QO01490H
Impact Factor
5.281
Authors
Lu-Yu Yan, Tian-Zhen Zhang, Ze-Zhong Lv, Ming-Chen Fu
View Original
Abstract
The development of novel radical precursors for the preparation of structurally diverse gem-difluoroalkenes is still in great demand, especially those enabled by metal-free catalysis. In this context, a metal-free photoinduced method for the synthesis of gem-difluoroalkenes was established, in which various carbonyl derivatives were successfully used as alkyl radical precursors via C–C bond cleavage to react with available α-trifluoromethylstyrenes. In particular, the successful gram-scale synthesis and late-stage modification for biologically active molecules highlights their potential value in drug discovery.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
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1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number:
60373-71-9
Molecular Formula:
C19H19N3O
2-Methyl-2-propanyl 2-carbamimidoyl-1-piperidinecarboxylate
CAS Number:
1258640-98-0
Molecular Formula:
C11H21N3O2
![1-oxaspiro[4.4]nonan-6-one structure](https://static.chemtradehub.com/structs/134/134179-01-4-e051.webp "1-oxaspiro[4.4]nonan-6-one structure")
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