Compound Q&A
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Answer
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of SMCC (sulfosuccinimidyl 4-(N-maleimido)butyrate) with lysine and subsequent conjugation with DM1 (dmabcamp, a maytansinoid). The key steps include activation of SMCC with EDC/NHS (N-hydroxysuccinimide/N-(3-dimethylaminopropyl) carbodiimide) to form a reactive ester, followed by coupling with lysine. The yield of the final conjugate is generally around 70-80%, with high selectivity for lysine residues.
About
CAS No
1281816-04-3
English Name
Lys-SMCC-DM1
Molecular Formula
C53H75ClN6O15S
Molecular Weight
1103.7299999999989 g/mol
SMILES
C[C@H]1[C@@H]2O[C@]2([C@H](CC(=O)N(c3c(c(cc(c3)C/C(=C/C=C/[C@H]([C@@]4(NC(=O)O[C@H]1C4)O)OC)/C)OC)Cl)C)OC(=O)[C@@H](N(C(=O)CCSC5C(=O)N(C(=O)C5)C[C@H]6CC[C@@H](CC6)C(=O)NCCCC[C@H](N)C(=O)O)C)C)C
InChIKey
UBRZDBDIKWWPEN-OZFINKIESA-N
Last Updated: 2026-03-04 21:35
