A DNA rotary nanodevice operated by enzyme-initiated strand resetting

Literature Information

Publication Date 2023-12-01
DOI 10.1039/D3CC05487J
Impact Factor 6.222
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Abstract

DNA nanostructures that respond to external stimuli have found applications in several areas such as biosensing, drug delivery and molecular computation. The use of different types of stimuli in a single operation provides another layer of control for the reconfiguration of nucleic acid nanostructures. This work demonstrates the use of a ribonuclease to “unset” a nucleic acid nanodevice based on the paranemic crossover (PX) DNA and specific DNA inputs to “reset” the structure into a juxtaposed DNA (JX2) configuration, resulting in a 180° rotation of the helical domains. Such operations would be useful in translational applications where DNA nanostructures can be designed to reconfigure on the basis of more than one stimulus.

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