Assembly and optically triggered disassembly of lipid–DNA origami fibers

Literature Information

Publication Date 2023-11-09
DOI 10.1039/D3CC04677J
Impact Factor 6.222
Authors

Sofia Julin, Eduardo Anaya-Plaza, Eeva Enlund


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Abstract

The co-assembly of lipids and other compounds has recently gained increasing interest. Here, we report the formation of stimuli-responsive lipid–DNA origami fibers through the electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades when exposed to UV-A light, which allows a photoinduced, controlled release of the 6HBs from the fibers. The presented complexation strategy may find uses in developing responsive nanomaterials e.g. for therapeutics.

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