Lead-oriented synthesis of epigenetic relevant scaffolds

Literature Information

Publication Date 2023-11-15
DOI 10.1039/D3CC04317G
Impact Factor 6.222
Authors

Timothé Maujean, Prakash Kannaboina, Adam I. Green, George M. Burslem


View Original

Abstract

A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2.

Related Literature

X-ray absorption spectroscopy and resonant inelastic scattering study of the first lithiation cycle of the Li-ion battery cathode Li2−xMnSiO4

M. Dahbi, T. Gustafsson, K. Edström, D. Newby, K. E. Smith, L.-C. Duda

2013-12-18 Paper

DOI: 10.1039/C3CP54103G

Large splittings of the 4f shell of Ce3+ in garnets

2013-11-25 Paper

DOI: 10.1039/C3CP53549E

Weak hydrogen bonding motifs of ethylamino neurotransmitter radical cations in a hydrophobic environment: infrared spectra of tryptamine+–(N2)n clusters (n ≤ 6)

Kenji Sakota, Markus Schütz, Matthias Schmies, Raphael Moritz, Aude Bouchet, Takamasa Ikeda, Yuuki Kouno, Hiroshi Sekiya, Otto Dopfer

2014-01-16 Paper

DOI: 10.1039/C3CP54127D

Effects of process parameters on the defects in graphene oxide–polyaniline composites investigated by positron annihilation spectroscopy

Utpal Rana, P. M. G. Nambissan, Sudip Malik, Kuntal Chakrabarti

2013-12-16 Paper

DOI: 10.1039/C3CP54032D

The molecular and magnetic structure of carbon-enclosed and partially covered Fe55 particles

Stefan Taubert, Kari Laasonen

2013-12-20 Paper

DOI: 10.1039/C3CP54491E

Progress on extending the light absorption spectra of photocatalysts

Zeyan Wang, Yuanyuan Liu, Baibiao Huang, Ying Dai, Zaizhu Lou, Gang Wang, Xiaoyang Zhang, Xiaoyan Qin

2013-11-11 Perspective

DOI: 10.1039/C3CP53817F

Graphene/g-C3N4 bilayer: considerable band gap opening and effective band structure engineering

Xinru Li, Ying Dai, Yandong Ma, Shenghao Han, Baibiao Huang

2014-01-06 Paper

DOI: 10.1039/C3CP54592J

The importance of timescale for hydrogen bonding in imidazolium chloride ionic liquids

Ioannis Skarmoutsos, Tom Welton, Patricia A. Hunt

2014-01-13 Paper

DOI: 10.1039/C3CP54551B

Mapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis

David Ruzafa, Lorena Varela, Ana I. Azuaga, Francisco Conejero-Lara, Bertrand Morel

2013-12-06 Paper

DOI: 10.1039/C3CP54383H

You might also like

Compound Q&A

What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?

N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...

52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A

What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?

When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...

1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A

What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?

Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...

628-39-7Diethyldiselane
Compound Q&A

What is the market or research trend for oxocopper (CAS: 12053-18-8)?

The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...

12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A

What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?

The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...

1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A

What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?

2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...

35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A

What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?

2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...

91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A

How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?

(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...

129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A

What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?

3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...

4857-42-53-Methyl-1,2-oxazole...
Compound Q&A

How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?

Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...

1281816-04-3Lys-SMCC-DM1

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.