Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles
Literature Information
Yingying Guo, Zhoulu Wang, Ying Zhu, Qiaochu Zhang, Donghui Wei, Xiang Liu, Zhenqian Fu
Formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione and dialkyl acetylene dicarboxylates has been successfully developed. A structurally diverse set of polyfunctionalized carbazoles was efficiently synthesized in acceptable to excellent yields. This reaction features H2O as the only by-product, has a broad substrate scope and proceeds under mild conditions.
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