Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles

Literature Information

Publication Date 2019-09-27
DOI 10.1039/C9QO01093A
Impact Factor 5.281
Authors

Yingying Guo, Zhoulu Wang, Ying Zhu, Qiaochu Zhang, Donghui Wei, Xiang Liu, Zhenqian Fu


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Abstract

Formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione and dialkyl acetylene dicarboxylates has been successfully developed. A structurally diverse set of polyfunctionalized carbazoles was efficiently synthesized in acceptable to excellent yields. This reaction features H2O as the only by-product, has a broad substrate scope and proceeds under mild conditions.

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DOI: 10.1039/D0CP90065F

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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