Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones
Literature Information
Songhai Huang, Pengfei Niu, Yingpeng Su, Dongcheng Hu, Congde Huo
A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing isoquinolinediones. This method also presents a new way to generate bromine radicals using a mild auto-oxidation pathway.
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