Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification
Literature Information
Joannie Desroches, Audrey Laurence, Michael Pinto, Marie-Andrée Tremblay, Kevin Petrecca, Frédéric Leblond
Ambient light artifacts can confound Raman spectroscopy measurements performed in a clinical setting such as during open surgery. However, requiring light sources to be turned off during intraoperative spectral acquisition can be impractical because it can slow down the procedure by requiring surgeons to acquire data under light conditions different from the routine clinical practice. Here a filter system is introduced allowing in vivo Raman spectroscopy measurements to be performed with the light source of a neurosurgical microscope turned on, without interfering with the standard procedure. Ex vivo and in vivo results on calf and human brain, respectively, show that when the new filter system is used there is no significant difference between Raman spectra acquired under pitch dark conditions or with the microscope light source turned on. This is important for the clinical translation of Raman spectroscopy because of the resulting decrease in total imaging time for each measurement and because the surgeon can now acquire spectroscopic data with no disruption of the surgical workflow.
Recommended Journals

Journal of Organometallic Chemistry

Molecular Pharmacology

Russian Chemical Reviews

Journal of Physics and Chemistry of Solids

Journal of Medicinal Chemistry

Journal of Heterocyclic Chemistry

Pharmacological Reviews

European Journal of Wood and Wood Products

Proceedings of the National Academy of Sciences of the United States of America

Journal of Catalysis
Related Literature
A variable temperature synchrotron X-ray diffraction study of the ferroelastic double perovskite Ba2GdMoO6
Thomas K. Wallace, Ross H. Colman, Abbie C. Mclaughlin
DOI: 10.1039/C2CP43732E
An all-cotton-derived, arbitrarily foldable, high-rate, electrochemical supercapacitor
Jiangli Xue, Yang Zhao, Huhu Cheng, Chuangang Hu, Yue Hu, Yuning Meng, Huibo Shao, Zhipan Zhang, Liangti Qu
DOI: 10.1039/C3CP51571K
Self-discharge of electrochemical double layer capacitors
Andrzej Lewandowski, Pawel Jakobczyk, Maciej Galinski, Marcin Biegun
DOI: 10.1039/C3CP44612C
Powder crystallography of pharmaceutical materials by combined crystal structure prediction and solid-state 1H NMR spectroscopy
Maria Baias, Cory M. Widdifield, Jean-Nicolas Dumez, Hugh P. G. Thompson, Timothy G. Cooper, Elodie Salager, Sirena Bassil, Robin S. Stein, Anne Lesage, Graeme M. Day, Lyndon Emsley
DOI: 10.1039/C3CP41095A
Local electronic structure of aqueous zinc acetate: oxygen K-edge X-ray absorption and emission spectroscopy on micro-jets
Edlira Suljoti, Kai F. Hodeck, Kathrin M. Lange, Mikhail A. Soldatov
DOI: 10.1039/C3CP50686J
A time resolved high energy X-ray diffraction study of cooling liquid SiO2
C. J. Benmore, M. C. Wilding, S. K. Tumber
DOI: 10.1039/C3CP44347G
ZnO nanoparticle based highly efficient CdS/CdSe quantum dot-sensitized solar cells
Chunhui Li, Lei Yang, Junyan Xiao, Yih-Chyng Wu, Martin Søndergaard, Yanhong Luo, Dongmei Li, Qingbo Meng, Bo Brummerstedt Iversen
DOI: 10.1039/C3CP50365H
Sieving di-branched from mono-branched and linear alkanes using ZIF-8: experimental proof and theoretical explanation
Marjo C. Mittelmeijer-Hazeleger, Miguel Angelo Granato, Vanessa F. Duarte Martins, Alírio E. Rodrigues, Gadi Rothenberg
DOI: 10.1039/C3CP44381G
How to interpret current–voltage relationships of blocking grain boundaries in oxygen ionic conductors
Seong K. Kim, Sergey Khodorov, Chien-Ting Chen, Sangtae Kim, Igor Lubomirsky
DOI: 10.1039/C3CP00145H
An ab initio investigation of Li2M0.5N0.5SiO4 (M, N = Mn, Fe, Co Ni) as Li-ion battery cathode materials
Sirous Asgari, Doretta Capsoni, Piercarlo Mustarelli
DOI: 10.1039/C3CP51481A
You might also like
What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?
N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...
What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?
When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...
What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?
Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...
What is the market or research trend for oxocopper (CAS: 12053-18-8)?
The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...
What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?
The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...
What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?
2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...
What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?
2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...
How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?
(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...
What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?
3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...
Source Journal
Analyst

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
![1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure 1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure](https://static.chemtradehub.com/structs/914/914637-08-4-8825.webp)


![1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one structure 1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one structure](https://static.chemtradehub.com/structs/603/60373-71-9-7dfb.webp)
