2-(4,4-Difluorobutyl)-1H-isoindole-1,3(2H)-dione
CAS Number:
1265341-14-7
Molecular Formula:
C12H11F2NO2
Label-free imaging of epidermal growth factor receptor-induced response in single living cells
Literature Information
Publication Date
2018-09-19
DOI
10.1039/C8AN01534A
Impact Factor
4.616
Authors
Zanying Peng, Jin Lu, Ling Zhang, Yang Liu, Jinghong Li
View Original
Abstract
Epidermal growth factor receptor (EGFR), which belongs to the second-largest protein family for cell signal transduction, plays crucial roles in homeostasis, cellular organized patterns and most human cancers. In EGFR-activated signaling networks, the detection of the spatial and temporal dynamics of cascades that encode the many cell fates is still a challenge. Here, we report real-time imaging of epidermal growth factor (EGF)-induced EGFR activation and its signaling cascade in single A431 cells using surface plasmon resonance (SPR) microscopy. A two-phase SPR response pattern was observed within 30 min after EGF treatment, including a positive SPR response that was related to the EGFR-activated mass redistribution in the first 600 s, and a subsequent negative SPR signal caused by the morphological change of the cells. Furthermore, the inhibitor analysis verified that AG1478 inhibited the response from the whole the cell, whereas cytochalasin B strongly inhibited the response from the cell edge region.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number:
60373-71-9
Molecular Formula:
C19H19N3O
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1226872-27-0
Molecular Formula:
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2-Methyl-2-propanyl 2-carbamimidoyl-1-piperidinecarboxylate
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Molecular Formula:
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