Reporting pH-sensitive drug release via unpaired spin fluorescence silencing
Literature Information
Publication Date
2018-01-10
DOI
10.1039/C7PY01942D
Impact Factor
5.582
Authors
Bettina Olshausen, Kathryn E. Fairfull-Smith, Ute Schepers
View Original
Abstract
We pioneer an approach for the visualization of pH-controlled molecular release of a fluorescent drug from a nitroxide polymer which combined yields a profluorescent system. A methacrylate-based terpolymer, bearing water-solubilizing triethylene-glycol chains, unpaired spins in the form of nitroxide and hydrazone-bound doxorubicin was synthesized to explore the possibilities of release quantification from profluorescent assemblies. Critically, we establish the fluorescence-silencing effect of polymer-bound nitroxides on covalently attached fluorophores and the overall accessibility of such constructs. The facile approach towards a functional assembly shown here provides an easy-to-assemble construct for complex delivery architectures towards applications in theranostics.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
(1H-Benzotriazol-1-yloxy)(di-1-pyrrolidinyl)methylium hexafluorophosphate
CAS Number:
105379-24-6
Molecular Formula:
C15H21F6N5OP
![4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline structure](https://static.chemtradehub.com/structs/120/120928-09-8-d3db.webp "4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline structure")
4-{2-[4-(2-Methyl-2-propanyl)phenyl]ethoxy}quinazoline
CAS Number:
120928-09-8
Molecular Formula:
C20H22N2O
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