4-Methoxy-3-nitroaniline

Basic Information

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CAS Number

577-72-0

Molecular Formula

C7H8N2O3

Molecular Weight

168.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

356.9℃ at 760 mmHg

Density

1.318

Flash Point

356.9 °C at 760 mmHg

Refractive Index

1.601

SMILES

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COC1=C(C=C(C=C1)N)[N+](=O)[O-]

InChI

InChI=1S/C7H8N2O3/c1-12-7-3-2-5(8)4-6(7)9(10)11/h2-4H,8H2,1H3

InChIKey

RUFOHZDEBFYQSV-UHFFFAOYSA-N

LogP

2.29000

Complexity

169

Safety Information

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Hazard Statement

Synonyms & References

English

577-72-0
EN300-126274
A8226
3-nitro-4-methoxyaniline
MFCD00134138
4-methoxy-3-nitro-phenylamine
AM20040759
CS-W002411
FT-0632425
A837301
SY005564
Q-102001
PS-3240
4-Amino-2-nitroanisole
4-Methoxy-3-nitroaniline
DTXSID40206408
4-methoxy-3-nitro-aniline
NS00033786
AC-7301
AO-801/41077431
SCHEMBL2211964
4-Methoxy-3-nitrobenzenamine
AKOS000291329
Z1201619226
p-Anisidine, 3-nitro-,
Benzenamine, 4-methoxy-3-nitro-
RUFOHZDEBFYQSV-UHFFFAOYSA-N
4-methoxy-3-nitrophenylamine
PubChem14815
KSC494S9F
5-Amino-2-methoxynitrobenzene

MDL Number

MFCD00134138

FAQ

What are the physical and chemical properties of 4-Methoxy-3-nitroaniline (CAS: 577-72-0)?

4-Methoxy-3-nitroaniline (CAS: 577-72-0) is a white crystalline solid with a molecular weight of approximately 180.11 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is known for its reactivity towards nucleophiles and electrophiles, making it useful in various chemical transformations.

How is 4-Methoxy-3-nitroaniline (CAS: 577-72-0) typically synthesized?

4-Methoxy-3-nitroaniline (CAS: 577-72-0) is commonly synthesized by the nitration of 4-methoxyaniline in the presence of a suitable nitration reagent, such as nitric acid and sulfuric acid. The reaction typically yields a 60-70% isolated yield and can be further refined using recrystallization techniques.

What industries use 4-Methoxy-3-nitroaniline (CAS: 577-72-0)?

4-Methoxy-3-nitroaniline (CAS: 577-72-0) finds applications in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various drugs. It is also used in the production of dyes, in sensors, and as a component in the development of certain polymers.

What precautions should be taken when handling 4-Methoxy-3-nitroaniline (CAS: 577-72-0)?

When handling 4-Methoxy-3-nitroaniline (CAS: 577-72-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately, and proper safety data sheets (SDS) should be consulted for detailed handling and disposal instructions.