Effects of bidirectional regulation on noises in gene networks

Literature Information

Publication Date 2010-01-20
DOI 10.1039/B912111K
Impact Factor 3.676
Authors

Yi Tao


View Original

Abstract

To investigate the effects of bidirectional regulation on the noise in protein concentration, a theoretical and simple three-gene network model is considered. The basic idea behind this model is from Paulsson’s proposition (J. Paulsson, Phys. Life Rev. 2005, 2, 157–175), where the synthesis and degradation of a mRNA species corresponding to a target protein are regulated directly and indirectly by a certain σ-factor, and a random increase in the concentration of the σ-factor should increase both the synthesis and degradation rates of the mRNA species (bidirectional regulation). Using the standard Ω-expansion technique (linear noise approximation) and Monte Carlo simulation, our main results show clearly that for the steady-state statistics the effects of the noise of the σ-factor on the stochastic fluctuation of the target protein could partially cancel out.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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