Efficient synthesis of 2,4,5-trisubstituted 2,5-chiral tetrahydropyridines using a one-pot asymmetric azaelectrocyclization protocol

Literature Information

Publication Date 2009-05-13
DOI 10.1039/B900897G
Impact Factor 6.222
Authors

Toyoharu Kobayashi, Kenichi Takeuchi, Junichi Miwa, Hiroshi Tsuchikawa, Shigeo Katsumura


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Abstract

The stereocontrolled synthetic procedure for the preparation of 2,4,5-trisubstituted 2,5-chiral 1,2,5,6-tetrahydropyridines was established using a one-pot asymmetric azaelectrocyclization protocol; the generality of this protocol was demonstrated by synthesizing the title compounds with various aryl and alkenyl substituents at the C-2 position.

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