A genetic selection system for evolving enantioselectivity of enzymes

Literature Information

Publication Date 2008-09-22
DOI 10.1039/B814538E
Impact Factor 6.222
Authors

Manfred T. Reetz, Horst Höbenreich, Pankaj Soni, Layla Fernández


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Abstract

As an alternative to screening in the directed evolution of enantioselective enzymes, a selection system has been implemented for a lipase-catalyzed hydrolytic kinetic resolution of a chiral ester.

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