N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide)

Basic Information

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CAS Number

218290-24-5

Molecular Formula

C18H20N4O2

Molecular Weight

324.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

171-176 °C

Specific Rotation

-95° (c 1, CH3OH)

SMILES

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C1CCC(C(C1)NC(=O)C2=CC=CC=N2)NC(=O)C3=CC=CC=N3

InChI

InChI=1S/C18H20N4O2/c23-17(15-9-3-5-11-19-15)21-13-7-1-2-8-14(13)22-18(24)16-10-4-6-12-20-16/h3-6,9-14H,1-2,7-8H2,(H,21,23)(H,22,24)/t13-,14-/m1/s1

InChIKey

BVYFDUZVVBXFBQ-ZIAGYGMSSA-N

LogP

1.9475999999999996

Topological Polar Surface Area

83.97999999999999 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

403

Synonyms & References

English

(1R,2R)-(-)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane, 97%
rel-N,N'-(1R,2R)-1,2-Cyclohexanediylbis[2-pyridinecarboxamide]
(1R,2R)-(-)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane
2-Pyridinecarboxamide, N,N'-(1R,2R)-1,2-cyclohexanediylbis-
N-[(1R, 2R)-2-(pyridine-2-carbonylamino)cyclohexyl]pyridine-2-carboxamide
N-[(1R,2R)-2-(pyridine-2-carbonylamino)cyclohexyl]pyridine-2-carboxamide
218290-24-5
SCHEMBL23425256
J-014308
(-)-N,N'-(1R,2R)-1,2-DIAMINOCYCLOHEXANEDIYLBIS(2-PYRIDINECARBOXAMIDE)
D81599
(+)-N,N'-(1S,2S)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)
(R,R)-DACH-pyridyl Trost ligand, 95%
N,N'-((1R,2R)-cyclohexane-1,2-diyl)dipicolinamide
(1R,2R)-(+)-1,2-Bis[(pyridin-2-ylcarbonyl)amino]cyclohexane
(R,R)-DACH-pyridyl TROST ligand
CS-17335
(1R,2R)-1,2-Bis(2-pyridinecarboxamido)cyclohexane
CS-0136203
AKOS030621879
(-)-N,N'-(1R,2R)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide
201551-23-7
MFCD02684543
(1R,2R)-( C)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane
N,N'-(trans-Cyclohexane-1,2-diyl)dipicolinamide
2-Pyridinecarboxamide,N,N'-(1R,2R)-1,2-cyclohexanediylbis-, rel- (9CI)
(1R,2R)-(–)-1,2-Bis[(2-pyridinylcarbonyl)amino]cyclohexane
(R,R)-DACH-pyridyl Trost ligand
Diaminocyclohexanediylbispyridinecarboxamide
(-)-N,N'-(1R,2R)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)
(-)-N,N-(1R,2R)-1,2-Diaminocyclohexanediylbis(2-pyridinecarboxamide)

MDL Number

MFCD02684543

FAQ

What are the physical and chemical properties of N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) (CAS: 218290-24-5)?

N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) is a crystalline solid with a molecular weight of approximately 332.19 g/mol. Its solubility in water is low, around 0.1 g/L. This compound exhibits good reactivity towards nucleophiles and can form stable complexes due to its amide and pyridine groups.

How is N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) (CAS: 218290-24-5) typically synthesized?

N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) can be synthesized via a multistep process starting from 1,2-cyclohexanediamine and 2-pyridinecarboxylic acid. The key steps involve amide formation and selective functional group introduction, achieved with mild conditions and suitable catalysts. Yield and selectivity can be optimized with careful control of reaction parameters.

What industries use N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) (CAS: 218290-24-5)?

N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) finds application in pharmaceuticals for its ability to form stable complexes with metal ions, which can enhance drug stability and bioavailability. It is also used in polymers for its excellent mechanical properties and in sensors for its sensitivity to certain chemical environments.

What precautions should be taken when handling N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide) (CAS: 218290-24-5)?

When handling N,N'-(1R,2R)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate non-flammable solvents, and the area should be thoroughly rinsed. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.