Investigation of the early stages in soraphen A biosynthesis

Literature Information

Publication Date 2003-05-19
DOI 10.1039/B303542P
Impact Factor 6.222
Authors

Alison M. Hill, Betty L. Thompson, Jonathan P. Harris, Roger Segret


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Abstract

The unusual benzoate starter unit in soraphen A derives from phenylalanine via cinnamate in a β-oxidative (plant-like) pathway; 3-phenyl-3-hydroxypropanoate incorporates directly into soraphen by loading onto module 2 of the PKS and indirectly from the β-oxidative pathway to generate benzoyl CoA.

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