(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (1:1) | CAS No. 99705-65-4
(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (1:1)
Basic Information
CAS Number
99705-65-4
Molecular Formula
C15H22ClNO2
Molecular Weight
283.8 g/mol
AD
Basic Physical Properties
Melting Point
303-305 ºC
Synonyms & References
English
- ZDA70565
- D05124
- Q27276897
- CHEMBL2106804
- 99705-65-4 (HCl)
- 99705-65-4
- trans-(+/-)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride
- MLS006010256
- (+/-)-PHNO hydrochloride
- Naxagolide hydrochloride [USAN]
- 2H-Naphth(1,2-b)-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, hydrochloride, (4aR-trans)-
- 2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, hydrochloride, trans- (9CI)
- (+)-(4aR,10bR)-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth(1,2-b)-1,4-oxazin-9-ol hydrochloride
- Naxagolide HCl
- NAXAGOLIDE HYDROCHLORIDE [MART.]
- PHNO hydrochloride, (+)-
- (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol;hydrochloride
- CS-0027623
- 100935-99-7
- Naxagolide (hydrochloride)
- L 647,339
- (4aR-trans)-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol Hydrochloride
- DTXSID60244221
- entNaxagolideHydrochloride
- L 647339; MK 458
- SMR004701331
- Naxagolide hydrochloride (USAN)
- (+)-PHNO Hydrochloride
- trans-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride
- A847237
- MK-458
MDL Number
MFCD10565902
FAQ
What are the physical and chemical properties of (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (CAS: 99705-65-4)?
(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride is a crystalline solid with a molecular weight of approximately 306.8 g/mol. It has a melting point of around 190-192°C and is slightly soluble in water. This compound exhibits good reactivity with common nucleophiles and can undergo various chemical transformations. It is also stable under normal temperature and pressure conditions, but care should be taken to avoid prolonged exposure to moisture and heat.
How is (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (CAS: 99705-65-4) typically synthesized?
The compound can be synthesized via a multi-step procedure, often involving the condensation of naphthalene derivatives followed by ring expansion and oxidation. The exact synthesis route may vary depending on the availability of starting materials and desired purity, but common methods include the use of reagents like acetic anhydride and sodium hydroxide under controlled conditions. The yield and selectivity of the reaction can be optimized by adjusting reaction parameters such as temperature and time.
What industries use (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (CAS: 99705-65-4)?
This compound is primarily used in the pharmaceutical industry for its potential as an intermediate in the synthesis of drugs. It also has applications in the polymer industry, where it can be used as a stabilizer or additive. Additionally, due to its unique chemical structure, it may be employed in the development of new sensor technologies and as a component in semiconductor manufacturing processes.
What precautions should be taken when handling (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride (CAS: 99705-65-4)?
When handling (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and protective clothing. Work should always be conducted in a well-ventilated area or a fume hood to minimize exposure to air. Spills should be cleaned up immediately using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed guidance on proper handling and disposal.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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