(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol

Basic Information

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CAS Number

99493-93-3

Molecular Formula

C9H9F3O

Molecular Weight

190.16 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

233 ºC

Density

1.234

Flash Point

98 ºC

SMILES

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CC(C1=CC=C(C=C1)C(F)(F)F)O

InChI

InChI=1S/C9H9F3O/c1-6(13)7-2-4-8(5-3-7)9(10,11)12/h2-6,13H,1H3/t6-/m0/s1

InChIKey

YMXIDIAEXNLCFT-LURJTMIESA-N

LogP

2.758700000000001

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

159

Safety Information

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Hazard Statement

Synonyms & References

English

Z809884560
99493-93-3
SCHEMBL5451341
AKOS017343729
CS-0039210
YMXIDIAEXNLCFT-LURJTMIESA-N
(1S)-1-[4-(trifluoromethyl)phenyl]ethanol
C77385
A858457
(S)-1-(4-(trifluoromethyl)phenyl)ethan-1-ol
(S)-1-[4-(Trifluoromethyl)phenyl]ethanol
EN300-54403
DS-5598
(S)-1-(4-(Trifluoromethyl)phenyl)ethanol
(1S)-1-[4-(Trifluoromethyl)phenyl]ethan-1-ol
MFCD03093007
(S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL
Benzenemethanol, a-methyl-4-(trifluoromethyl)-, (aS)-
(-)-1-(p-Trifluoromethylphenyl)ethanol
(S)-1-[p-(Trifluoromethyl)phenyl]ethanol

MDL Number

MFCD03093008

FAQ

What are the physical and chemical properties of (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol (CAS: 99493-93-3)?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is a colorless liquid with a molecular weight of approximately 231.13 g/mol. It has a crystalline form at room temperature and its solubility in water is low. This compound is reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions. It is slightly soluble in water and miscible with common organic solvents.

How is (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol (CAS: 99493-93-3) typically synthesized?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is typically synthesized via a Suzuki coupling reaction between 4-bromophenyl trifluoroacetate and (S)-2-bromopropanol. Palladium(II) acetate and a phase transfer catalyst are used as catalysts, achieving excellent selectivity and yield. The reaction is conducted in the presence of a base like triphenylphosphine.

What industries use (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol (CAS: 99493-93-3)?

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is used in the pharmaceutical industry for the synthesis of various drugs, as well as in polymer manufacturing for the production of special plastics and coatings. It also finds applications in the sensor industry for developing gas sensors and in semiconductor manufacturing as a cleaning agent.

What precautions should be taken when handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol (CAS: 99493-93-3)?

When handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol, ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and disposal.