(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol(CAS: 99493-93-3)

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is a colorless liquid with a molecular weight of approximately 231.13 g/mol. It has a crystalline form at room temperature and its solubility in water is low. This compound is reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions. It is slightly soluble in water and miscible with common organic solvents.

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is typically synthesized via a Suzuki coupling reaction between 4-bromophenyl trifluoroacetate and (S)-2-bromopropanol. Palladium(II) acetate and a phase transfer catalyst are used as catalysts, achieving excellent selectivity and yield. The reaction is conducted in the presence of a base like triphenylphosphine.

(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is used in the pharmaceutical industry for the synthesis of various drugs, as well as in polymer manufacturing for the production of special plastics and coatings. It also finds applications in the sensor industry for developing gas sensors and in semiconductor manufacturing as a cleaning agent.

When handling (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol, ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and disposal.