Compound Q&A
How is (1S)-1-[4-(Trifluoromethyl)phenyl]ethanol (CAS: 99493-93-3) typically synthesized?
Answer
![(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol](https://static.chemtradehub.com/structs/994/99493-93-3-41bc.webp "(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol")
(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol is typically synthesized via a Suzuki coupling reaction between 4-bromophenyl trifluoroacetate and (S)-2-bromopropanol. Palladium(II) acetate and a phase transfer catalyst are used as catalysts, achieving excellent selectivity and yield. The reaction is conducted in the presence of a base like triphenylphosphine.
About
CAS No
99493-93-3
English Name
(1S)-1-[4-(Trifluoromethyl)phenyl]ethanol
Molecular Formula
C9H9F3O
Molecular Weight
190.16 g/mol
SMILES
CC(C1=CC=C(C=C1)C(F)(F)F)O
InChIKey
YMXIDIAEXNLCFT-LURJTMIESA-N
Last Updated: 2025-10-28 10:54
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