7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine | CAS No. 945553-94-6
7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
Basic Information
CAS Number
945553-94-6
Molecular Formula
C20H12ClFN4O4S
Molecular Weight
458.85 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 4-(3-Chloro-4-fluoroaniline)-7-Phenylsulfonyl-6-nitroquinazoline
- N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine
- 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
- N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinamine
- (7-Phenylsulfonyl-6-nitro-chinazolin-4-yl)-(3-chlor-4-fluor-phenyl)-amin
- 7-(Benzenesulfonyl)-N-(3-chloro-4-fluoro-phenyl)-6-nitro-quinazolin-4-amine
- IBXBOQKFZSMVOL-UHFFFAOYSA-N
- SB11869
- AK171
- N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-4-quinazolinamine (ACI)
- 7-(benzenesulfonyl)-N-(3-chloro-4-fluoro-phenyl)-6-nitro-quinazolin-4-amine
- EC 620-069-6
- n-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine
- C20H12ClFN4O4S
- VMB55394
- AKOS025290977
- MFCD17018718
- DTXSID10893728
- SCHEMBL1366567
- DB-158971
- NS00005522
- AS-34025
- 4-(3-chloro-4-fluoro-phenylamino)-7-(phenylsulphonyl)-6-nitro-quinazoline
- 945553-94-6
- SY098094
- CS-0050131
MDL Number
MFCD17018718
FAQ
What are the physical and chemical properties of 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (CAS: 945553-94-6)?
7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is a crystalline solid with a molecular weight of approximately 493.2 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. The compound is known for its low reactivity in basic media but can undergo hydrolysis in acidic conditions. It is stable under normal storage conditions but should be protected from moisture and light.
How is 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (CAS: 945553-94-6) typically synthesized?
This compound is typically synthesized through a multi-step reaction involving sulfonylation, nitration, and coupling steps. Common catalysts include sulfonic acids and Lewis acids. The synthesis involves the protection of the amino group, followed by sulfonylation, nitration, and deprotection. The overall yield is around 50-60%, with good selectivity for the desired product.
What industries use 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (CAS: 945553-94-6)?
This compound is primarily used in pharmaceutical research for its potential as an intermediate or lead compound. It may also have applications in the development of sensors and as a precursor in the synthesis of other quinazoline derivatives. While not widely used in polymers or semiconductors, its unique chemical structure makes it a valuable reagent in these fields.
What precautions should be taken when handling 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (CAS: 945553-94-6)?
When handling 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine, it is essential to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. It should be stored in a cool, dry, and well-ventilated area. In case of a spill, it is recommended to use a fume hood and consult the Safety Data Sheet (SDS) for specific cleanup procedures. The compound should be handled with care due to its potential to undergo hydrolysis in acidic conditions and its low solubility in water.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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