Compound Q&A
How is 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (CAS: 945553-94-6) typically synthesized?
Answer
This compound is typically synthesized through a multi-step reaction involving sulfonylation, nitration, and coupling steps. Common catalysts include sulfonic acids and Lewis acids. The synthesis involves the protection of the amino group, followed by sulfonylation, nitration, and deprotection. The overall yield is around 50-60%, with good selectivity for the desired product.
About
CAS No
945553-94-6
English Name
7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
Molecular Formula
C20H12ClFN4O4S
Molecular Weight
458.85 g/mol
SMILES
C1=CC=C(C=C1)S(=O)(=O)C2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)[N+](=O)[O-]
InChIKey
IBXBOQKFZSMVOL-UHFFFAOYSA-N
Last Updated: 2026-01-01 10:50
