7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(CAS: 945553-94-6)

7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine is a crystalline solid with a molecular weight of approximately 493.2 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. The compound is known for its low reactivity in basic media but can undergo hydrolysis in acidic conditions. It is stable under normal storage conditions but should be protected from moisture and light.

This compound is typically synthesized through a multi-step reaction involving sulfonylation, nitration, and coupling steps. Common catalysts include sulfonic acids and Lewis acids. The synthesis involves the protection of the amino group, followed by sulfonylation, nitration, and deprotection. The overall yield is around 50-60%, with good selectivity for the desired product.

This compound is primarily used in pharmaceutical research for its potential as an intermediate or lead compound. It may also have applications in the development of sensors and as a precursor in the synthesis of other quinazoline derivatives. While not widely used in polymers or semiconductors, its unique chemical structure makes it a valuable reagent in these fields.

When handling 7-(benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine, it is essential to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. It should be stored in a cool, dry, and well-ventilated area. In case of a spill, it is recommended to use a fume hood and consult the Safety Data Sheet (SDS) for specific cleanup procedures. The compound should be handled with care due to its potential to undergo hydrolysis in acidic conditions and its low solubility in water.