Ponatinib | CAS No. 943319-70-8

Ponatinib

Basic Information

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CAS Number

943319-70-8

Molecular Formula

C29H27F3N6O

Molecular Weight

532.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>160 °C

Density

1.3

Solubility

In water, 9.0X10-2 mg/L at 25 °C (est)

Vapor Pressure

2.5X10-17 mm Hg at 25 °C (est)

SMILES

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CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

InChI

InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)

InChIKey

PHXJVRSECIGDHY-UHFFFAOYSA-N

LogP

4.40480

Complexity

910

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AP24534(Ponatinib)
1-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ponatinib
Ponatinib (AP24534)
3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
AP24534
AP-24534
AP24534 Ponatinib
Ponatinb
Ponatinib (AP24534,Iclusig®)
Ponatinib C
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methy...
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
AP 24534
Iclusig
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
4340891KFS
3-(Imidazo[1,2-B]pyridazin-3-Ylethynyl)-4-Methyl-N-{4-[(4-Methylpiperazin-1-Yl)methyl]-3-(Trifluoromethyl)phenyl}benzamide
C29H27F3N6O
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(tr
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide (ACI)
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
NSC-800855
MLS006010166
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam
DTXCID50163917
CS-0204
HMS3654H16
PONATINIB [MI]
PONATINIB [WHO-DD]
AS-19133

MDL Number

MFCD17215203

FAQ

What is Ponatinib (CAS: 943319-70-8)?

Ponatinib is a kinase inhibitor with the chemical formula C23H26N4O5. It is a yellow solid with high solubility in dimethyl sulfoxide (DMSO) and is known for its ability to target multiple tyrosine kinases, including BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) and other cancers.

What are the main uses of Ponatinib (CAS: 943319-70-8)?

Ponatinib is primarily used in oncology, particularly for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is also being investigated for use in other cancers due to its broad kinase inhibitory activity.

Is Ponatinib (CAS: 943319-70-8) safe?

Ponatinib is generally considered safe when used under medical supervision, but it may have side effects such as arterial thrombosis, arrhythmias, and liver toxicity. Proper handling and adherence to safety guidelines are essential to minimize risks during its use and storage.

How should Ponatinib (CAS: 943319-70-8) be stored?

Ponatinib should be stored in a cool, dry place, away from light, at a temperature between 2°C to 8°C. It is typically kept in a tightly sealed container to prevent moisture exposure and maintain its stability and potency over time.