4-(Trifluoromethoxy)benzylamine

Basic Information

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CAS Number

93919-56-3

Molecular Formula

C8H8F3NO

Molecular Weight

191.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

57-60 °C/10 mmHg

Density

1.252 g/mL at 25 °C

Refractive Index

n20/D 1.452(lit.)

SMILES

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C1=CC(=CC=C1CN)OC(F)(F)F

InChI

InChI=1S/C8H8F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H,5,12H2

InChIKey

DBGROTRFYBSUTR-UHFFFAOYSA-N

LogP

2.0439

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

152

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

(4-(Trifluoromethoxy)phenyl)methanamine
4-(Trifluoromethoxy)benzylamine
[4-(trifluoromethoxy)phenyl]methanamine
1-[4-(Trifluoromethoxy)phenyl]methanamine
p-(Trifluoromethoxy)benzylamine
((4-(Trifluoromethoxy)phenyl)methyl)amine
Benzenemethanamine, 4-(trifluoromethoxy)-
4-trifluoromethoxybenzylamine
4-(trifluoromethoxy)benzyl amine
p-trifluoromethoxybenzylamine
DBGROTRFYBSUTR-UHFFFAOYSA-N
[4-(trifluoromethoxy)phenyl]methylamine
p-trifluoromethoxybenzyl amine
Pu
4-(Trifluoromethoxy)benzenemethanamine (ACI)
[4-(Trifluoromethoxy)phenyl]methanamine
p-Trifluoromethoxybenzylamine
1-[4-(trifluoromethoxy)phenyl]methanamine
MFCD00061237
EINECS 300-040-1
DTXSID20239895
4-trifluoromethoxy-benzylamine
F2145-0705
[4-(Trifluoromethoxy)phenyl]methanamine #
(4-trifluoromethoxyphenyl)methanamine
EN300-25596
Q27452013
J-513899
Z212046238
AKOS000264340
AC-2348

MDL Number

MFCD00061237

Customs Code

2922199090

FAQ

What are the physical and chemical properties of 4-(Trifluoromethoxy)benzylamine (CAS: 93919-56-3)?

4-(Trifluoromethoxy)benzylamine is a colorless to white crystalline solid with a molecular weight of 279.15 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dichloromethane. It is moderately reactive, particularly towards nucleophiles. The compound is known for its stability but should be stored in a cool, dark place to prevent photodegradation.

How is 4-(Trifluoromethoxy)benzylamine (CAS: 93919-56-3) typically synthesized?

4-(Trifluoromethoxy)benzylamine is typically synthesized via the reduction of 4-(trifluoromethoxy)benzyl nitrile using sodium borohydride or lithium aluminium hydride as a reducing agent. The reaction is performed in anhydrous solvents like tetrahydrofuran (THF) under inert atmosphere to ensure high selectivity and yield.

What industries use 4-(Trifluoromethoxy)benzylamine (CAS: 93919-56-3)?

4-(Trifluoromethoxy)benzylamine is primarily used in the pharmaceutical industry as a precursor for the synthesis of various medicinal compounds, including certain antiviral and antifungal drugs. It also finds applications in the polymer industry for the production of novel polymers, and in the semiconductor industry for specific etching processes.

What precautions should be taken when handling 4-(Trifluoromethoxy)benzylamine (CAS: 93919-56-3)?

When handling 4-(Trifluoromethoxy)benzylamine, it is essential to wear appropriate personal protective equipment (PPE) including safety goggles, gloves, and a lab coat. This compound should be handled in a well-ventilated area or under a fume hood due to its potential for airborne exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.