2-Bromo-6-chloro-3-nitropyridine

Basic Information

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CAS Number

91678-23-8

Molecular Formula

C5H2BrClN2O2

Molecular Weight

237.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

277.2±35.0 ºC (760 Torr),

Density

1.936±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

121.5±25.9 ºC,

SMILES

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C1=CC(=NC(=C1[N+](=O)[O-])Br)Cl

InChI

InChI=1S/C5H2BrClN2O2/c6-5-3(9(10)11)1-2-4(7)8-5/h1-2H

InChIKey

WISCKHBEOBONJA-UHFFFAOYSA-N

LogP

2.92890

Complexity

163

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Bromo-6-chloro-3-nitropyridine
6-bromo-3-chloro-2-nitropyridine
Pyridine,2-bromo-6-chloro-3-nitro-
2-Bromo-3-nitro-6-chloropyridine
Pyridine, 2-bromo-6-chloro-3-nitro-
2-BROMO-6-CHLORO-3-NITRO-PYRIDINE
WISCKHBEOBONJA-UHFFFAOYSA-N
RW3189
VP13670
FCH1391879
ST2416604
AX8072031
AB0027644
W9498
2-Bromo-6-chloro-3-nitropyridine (ACI)
2-bromo-6-chloro-3-nitro-pyridine
DB-027133
DS-12173
SY112596
SCHEMBL3273393
91678-23-8
AKOS015835816
2-BROMO-6-CHLORO-3-NITROPYRIDINE
SB39910
J-508437
DTXSID70531639
CS-W008871
MFCD09260904

MDL Number

MFCD09260904

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Bromo-6-chloro-3-nitropyridine (CAS: 91678-23-8)?

2-Bromo-6-chloro-3-nitropyridine is a crystalline solid with a molecular weight of approximately 222.01 g/mol. It is sparingly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound is highly reactive due to its electron-withdrawing nitro group, making it a versatile intermediate in organic synthesis. It is prone to hydrolysis under basic conditions and can undergo substitution reactions at the bromo and chloro positions.

How is 2-Bromo-6-chloro-3-nitropyridine (CAS: 91678-23-8) typically synthesized?

2-Bromo-6-chloro-3-nitropyridine is typically synthesized via electrophilic substitution reactions. Common methods include the reaction of 6-chloro-3-nitropyridine with bromine in the presence of a Lewis acid like aluminum bromide. The yield and selectivity can be optimized by adjusting the reaction conditions and solvents. This process is often carried out under mild conditions to avoid overbromination or other unwanted side reactions.

What industries use 2-Bromo-6-chloro-3-nitropyridine (CAS: 91678-23-8)?

2-Bromo-6-chloro-3-nitropyridine is used in pharmaceuticals for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the preparation of functionalized polymers. Additionally, this compound can be employed in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

What precautions should be taken when handling 2-Bromo-6-chloro-3-nitropyridine (CAS: 91678-23-8)?

When handling 2-Bromo-6-chloro-3-nitropyridine, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This substance should be handled in a fume hood to minimize exposure to its fumes. In case of a spill, it is recommended to immediately clean up the area using appropriate absorbent materials and follow standard safety protocols. Always consult the Safety Data Sheet (SDS) for specific handling and emergency procedures.