Neratinib Maleate

Basic Information

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CAS Number

915942-22-2

Molecular Formula

C34H36ClN5O7

Molecular Weight

662.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C.C(=CC(=O)O)C(=O)O

InChI

InChI=1S/C30H32ClN5O3.C4H4O4/c1-5-38-28-17-25-23(16-26(28)35-29(37)10-8-14-36(3)4)30(20(2)18-33-25)34-21-11-12-27(24(31)15-21)39-19-22-9-6-7-13-32-22;5-3(6)1-2-4(7)8/h6-13,15-18H,5,14,19H2,1-4H3,(H,33,34)(H,35,37);1-2H,(H,5,6)(H,7,8)/b10-8+;2-1-

InChIKey

ZLRINKRBPGHRLB-AJOUBPDISA-N

LogP

6.081020000000006

Topological Polar Surface Area

163.21 Å²

Hydrogen Bond Donor/Acceptor

4 / 12

Complexity

1000

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Neratinib Maleate
9RM7XY23ZS
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide Maleate
Neratinib maleate [MI]
Nerlynx (TN)
HKI272
BCP28677
2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1)
D10898
Q27272985
(2E)-N-(4-((3-Chloro-4-((pyridin-2-yl)methoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide maleate
(E)-N-[4-[3-Chloro-4-(2-pyridinylmethyloxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide maleate
(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide maleate
Neratinib maleate
Nerlynx
915942-22-2 (maleate)
DB-210727
UNII-9RM7XY23ZS
NERATINIB MALEATE ANHYDROUS
CHEMBL3989921
HY-32721B
Neratinib (maleate)
hki-272 maleate
NERATINIB MALEATE [ORANGE BOOK]
BN160240
(Z)-but-2-enedioic acid;(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
DS-19892
CS-0030935
(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide maleate
D71134
915942-22-2

MDL Number

MFCD20489458

FAQ

What is Neratinib Maleate (CAS: 915942-22-2)?

Neratinib Maleate is a potent irreversible tyrosine kinase inhibitor, primarily used in the treatment of HER2-positive metastatic breast cancer. It has the chemical formula C22H25N3O5.H2C2O4 and is known for its ability to inhibit multiple HER family members, including HER1, HER2, and HER4.

What are the main uses of Neratinib Maleate (CAS: 915942-22-2)?

Neratinib Maleate is mainly used to treat HER2-positive metastatic breast cancer. It is also investigated for its potential in treating other types of cancers, such as colorectal cancer and gastric cancer, due to its broad spectrum of activity against HER family members.

Is Neratinib Maleate (CAS: 915942-22-2) safe?

Neratinib Maleate is generally considered safe when used as directed. However, it can cause side effects such as diarrhea, rash, and hyperglycemia. Patients should follow medical advice, regularly monitor health, and take necessary precautions to avoid adverse reactions.

How should Neratinib Maleate (CAS: 915942-22-2) be stored?

Neratinib Maleate should be stored at room temperature (15-30°C) away from direct sunlight and moisture. It should be kept in a tightly sealed container to maintain its stability and efficacy. Avoid exposure to extreme temperatures or humidity, as this may affect its potency and safety.