Flurbiprofen Axetil

Basic Information

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CAS Number

91503-79-6

Molecular Formula

C19H19FO4

Molecular Weight

330.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

424.3℃ at 760 mmHg

Density

1.169

SMILES

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CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OC(C)OC(=O)C

InChI

InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3

InChIKey

ALIVXCSEERJYHU-UHFFFAOYSA-N

LogP

4.048500000000003

Topological Polar Surface Area

52.6 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

433

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Synonyms & References

English

[1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-methyl-,1-(acetyloxy)ethyl ester
1-Acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate
1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate
Flurbiprofen Axetil
Flurbiprofen Axetil (Mixture of Diastereomers)
1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate
CC5013
FP 83
Lenalidomide
LFP 83
Lipfen
Lipo-flurbiprofen axetil
Liposomal flurbiprofen axetil
Ropion
Ropiopn
1-Acetoxyethyl 2-(2-Fluoro-4-biphenylyl)propionate (mixture of diastereoisomers)
2-(2-Fluoro-4-biphenylyl)propionic Acid 1-Acetoxyethyl Ester (mixture of diastereoisomers)
2-Fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetic acid 1-(acetyloxy)ethyl ester
1-acetoxyethyl 2-(2-fluorobiphenyl-4-yl)propanoate
1-Acetoxyethyl-2-(2-fluoro-4-biphenylyl)propionate
AK163527
4-Biphenylacetic acid, 2-fluoro-alpha-methyl-, 1-acetoxyethyl ester
2-Fluoro-alpha-methyl-(1,1'-bipheny
1-Acetoxyethyl 2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanoate
Flurbiprofen axetil
1-acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate
MFCD00900049
AKOS024464989
FLURBIPROFEN AXETIL [WHO-DD]
F1176
1-(acetyloxy)ethyl 2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoate

MDL Number

MFCD00900049

FAQ

What are the physical and chemical properties of Flurbiprofen Axetil (CAS: 91503-79-6)?

Flurbiprofen Axetil (CAS: 91503-79-6) is a crystalline solid with a molecular weight of approximately 349.37 g/mol. It is sparingly soluble in water but more soluble in organic solvents like ethanol. Chemically, it is relatively stable under normal conditions but can degrade when exposed to heat or light. It has a pKa of about 3.7, indicating it is weakly acidic.

How is Flurbiprofen Axetil (CAS: 91503-79-6) typically synthesized?

Flurbiprofen Axetil is typically synthesized through a esterification reaction between flurbiprofen and acetic anhydride, followed by acetylation. Common catalysts include acid catalysts like sulfuric acid. The reaction is carried out under mild conditions to achieve high selectivity and yield, with purification steps involving recrystallization and vacuum drying.

What industries use Flurbiprofen Axetil (CAS: 91503-79-6)?

Flurbiprofen Axetil (CAS: 91503-79-6) is primarily used in the pharmaceutical industry as an anti-inflammatory drug. It is also used in some cosmetic products for its anti-inflammatory and analgesic properties. Its chemical structure makes it suitable for incorporation into topical and oral medications.

What precautions should be taken when handling Flurbiprofen Axetil (CAS: 91503-79-6)?

When handling Flurbiprofen Axetil (CAS: 91503-79-6), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the work is done in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from sources of heat and light. In case of spill, immediately clean up using appropriate techniques and refer to the Material Safety Data Sheet (MSDS) for detailed instructions.