Flurbiprofen Axetil(CAS: 91503-79-6)

Flurbiprofen Axetil (CAS: 91503-79-6) is a crystalline solid with a molecular weight of approximately 349.37 g/mol. It is sparingly soluble in water but more soluble in organic solvents like ethanol. Chemically, it is relatively stable under normal conditions but can degrade when exposed to heat or light. It has a pKa of about 3.7, indicating it is weakly acidic.

Flurbiprofen Axetil is typically synthesized through a esterification reaction between flurbiprofen and acetic anhydride, followed by acetylation. Common catalysts include acid catalysts like sulfuric acid. The reaction is carried out under mild conditions to achieve high selectivity and yield, with purification steps involving recrystallization and vacuum drying.

Flurbiprofen Axetil (CAS: 91503-79-6) is primarily used in the pharmaceutical industry as an anti-inflammatory drug. It is also used in some cosmetic products for its anti-inflammatory and analgesic properties. Its chemical structure makes it suitable for incorporation into topical and oral medications.

When handling Flurbiprofen Axetil (CAS: 91503-79-6), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the work is done in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from sources of heat and light. In case of spill, immediately clean up using appropriate techniques and refer to the Material Safety Data Sheet (MSDS) for detailed instructions.