Ethyl (4-hydroxy-3,5-diiodophenyl)acetate | CAS No. 90917-49-0

Ethyl (4-hydroxy-3,5-diiodophenyl)acetate

Basic Information

CAS Number

90917-49-0

Molecular Formula

C10H10I2O3

Molecular Weight

431.99 g/mol

AD

Basic Physical Properties

CCOC(=O)CC1=CC(=C(C(=C1)I)O)I

InChI

InChI=1S/C10H10I2O3/c1-2-15-9(13)5-6-3-7(11)10(14)8(12)4-6/h3-4,14H,2,5H2,1H3

InChIKey

OICDFUWSAQEXEK-UHFFFAOYSA-N

LogP

2.707000000000001

Topological Polar Surface Area

46.53 Ų

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

211

Synonyms & References

English

  • NS00039378
  • BCP33819
  • 3,5-Diiodo-4-hydroxyphenylacetic Acid Ethyl Ester
  • 8RQL2M9RUS
  • Benzeneacetic acid, 4-hydroxy-3,5-diiodo-, ethyl ester
  • Levothyroxine Sodium Impurity 4
  • 90917-49-0
  • UNII-8RQL2M9RUS
  • ethyl 2-(4-hydroxy-3,5-diiodophenyl)acetate
  • F11930
  • N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine Sodium Salt
  • ethyl2-(4-hydroxy-3,5-diiodophenyl)acetate
  • Ethyl 4-hydroxy-3,5-diiodophenylacetate
  • EINECS 292-689-1
  • DTXSID10238317
  • AKOS027339742
  • Benzeneacetic acid,4-hydroxy-3,5-diiodo-, ethyl ester
  • ETHYL 4-HYDROXY-3,5-DIIODOPHENYLACETATE

MDL Number

MFCD28098320

FAQ

What are the physical and chemical properties of Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0)?

Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0) is a crystalline solid with a high molecular weight. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is known for its low reactivity and stability under normal conditions. It does not readily undergo typical organic transformations such as nucleophilic substitution or alkylation due to its bulky and stable iodine substituents.

How is Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0) typically synthesized?

Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0) can be synthesized via a multistep process involving the iodination of an aromatic ring, followed by acetylation of the hydroxy group. Commonly, the iodination step involves the use of iodine and a Lewis acid catalyst, such as aluminum triisopropoxide. The acetylation step is achieved using acetyl chloride in the presence of a base like pyridine. The overall yield and selectivity are dependent on the reaction conditions and catalysts used.

What industries use Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0)?

Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0) is primarily used in the pharmaceutical industry for the synthesis of advanced intermediates. It also finds applications in the production of certain organic pigments and dyes due to its color and stability. Additionally, this compound may be used in research and development for its unique chemical properties.

What precautions should be taken when handling Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0)?

When handling Ethyl (4-hydroxy-3,5-diiodophenyl)acetate (CAS: 90917-49-0), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, immediately contain it and clean up using appropriate chemical spill kits. Always refer to the Material Safety Data Sheet (MSDS) for detailed information on handling and emergency procedures.

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