Muramidase | CAS No. 9066-59-5

Muramidase

Basic Information

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CAS Number

9066-59-5

Molecular Formula

C125H196N40O36S2

Molecular Weight

2899.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(=O)N)C(=O)O)NC(=O)CNC(=O)C(CC3=CN=CN3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CC4=CC=CC=C4)NC(=O)C(C(C)C)N

InChI

InChI=1S/C125H196N40O36S2/c1-61(2)43-80(105(183)141-57-97(174)151-89(122(200)201)51-93(128)170)157-119(197)90(58-166)164-115(193)84(47-69-27-31-72(167)32-28-69)150-96(173)55-140-104(182)74(24-18-39-137-123(130)131)153-116(194)85(48-70-29-33-73(168)34-30-70)159-117(195)87(50-92(127)169)161-118(196)88(52-99(177)178)162-114(192)81(44-62(3)4)149-95(172)56-143-107(185)86(49-71-53-136-60-144-71)160-110(188)77(26-20-41-139-125(134)135)155-109(187)76(23-16-17-38-126)154-112(190)79(37-42-203-12)152-103(181)67(11)146-101(179)65(9)145-102(180)66(10)147-113(191)82(45-63(5)6)158-111(189)78(35-36-98(175)176)156-120(198)91(59-202)165-108(186)75(25-19-40-138-124(132)133)148-94(171)54-142-106(184)83(46-68-21-14-13-15-22-68)163-121(199)100(129)64(7)8/h13-15,21-22,27-34,53,60-67,74-91,100,166-168,202H,16-20,23-26,35-52,54-59,126,129H2,1-12H3,(H2,127,169)(H2,128,170)(H,136,144)(H,140,182)(H,141,183)(H,142,184)(H,143,185)(H,145,180)(H,146,179)(H,147,191)(H,148,171)(H,149,172)(H,150,173)(H,151,174)(H,152,181)(H,153,194)(H,154,190)(H,155,187)(H,156,198)(H,157,197)(H,158,189)(H,159,195)(H,160,188)(H,161,196)(H,162,192)(H,163,199)(H,164,193)(H,165,186)(H,175,176)(H,177,178)(H,200,201)(H4,130,131,137)(H4,132,133,138)(H4,134,135,139)/t65-,66-,67-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-/m0/s1

InChIKey

JFXJPYIEDZSWNF-JWBGUOTLSA-N

LogP

-13.312690000000028

Topological Polar Surface Area

1252.6899999999996 Å²

Hydrogen Bond Donor/Acceptor

52 / 76

Complexity

6500

Safety Information

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Stability

Stable. Store cold. Incompatible with strong oxidizing agents.

Synonyms & References

English

Lysozyme chloride
9066-59-5
AT25334
Globulin G1
Muramidase
Lysozyme hydrochloride
Muramidase hydrolase
Murazyme
Lysozyme Chloride from Egg white
LYSOZYME CHLORIDE, FROM EGG WHITE 18000 UNITS
Mucopeptide N-acetylmuramoylhydrolase

MDL Number

MFCD00198076

FAQ

What are the physical and chemical properties of Muramidase (CAS: 9066-59-5)?

Muramidase, also known as N-acetylmuramidase, is a hydrolase enzyme. It has a molecular weight of approximately 45 kDa. Muramidase is highly soluble in water and is stable in neutral to slightly alkaline solutions. It is not significantly affected by common organic solvents. The enzyme exhibits high activity at a pH range of 6.0 to 8.0 and is most active at around pH 7.0. It is known for its broad substrate specificity and can hydrolyze the β-1,4-glycosidic bond in peptidoglycan, making it a valuable tool in the study of bacterial cell wall metabolism.

How is Muramidase (CAS: 9066-59-5) typically synthesized?

Muramidase can be synthesized through genetic engineering techniques, such as expressing the gene encoding muramidase in heterologous hosts like E. coli. The enzyme is typically produced using recombinant DNA technology. The yield is influenced by factors such as the expression vector, host cell, and cultivation conditions. The process often involves expression in a host cell, followed by purification through column chromatography and other biochemical methods to obtain a homogeneous enzyme preparation.

What industries use Muramidase (CAS: 9066-59-5)?

Muramidase finds applications in various industries. In the pharmaceutical sector, it is used for the development of diagnostic kits and as an enzyme component in antimicrobial treatments. In the food industry, it can be used to improve the quality of food products by breaking down bacterial cell walls. Additionally, it is used in the production of enzymes for biodegradable polymers and in biosensors for detecting bacterial contamination. Its use in semiconductors for cleaning and surface modification is also growing.

What precautions should be taken when handling Muramidase (CAS: 9066-59-5)?

When handling Muramidase, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with caution, using appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions. Proper storage should be in a cool, dry place away from direct sunlight and heat sources.