L-Asparaginase

Basic Information

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CAS Number

9015-68-3

Molecular Formula

C14H17NO4S

Molecular Weight

295.35 g/mol

EINECS

232-765-3

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Crystals or powder

Melting Point

No data available

Boiling Point

No data available

Density

1.4±0.1 g/cm3

Flash Point

No data available

Specific Rotation

D20 -30 to -32°

SMILES

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c1ccc2c(c1)c(=O)[nH]s2

InChI

InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)

InChIKey

DMSMPAJRVJJAGA-UHFFFAOYSA-N

LogP

1.5895999999999997

Topological Polar Surface Area

32.86 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

508

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1(a) Class 6.1(a)

Toxicity

TDLo ims-chd: 8145 iu/kg/1W:SYS CANCAR 34,780,74

Synonyms & References

English

Asparaginase (usan 8ci 9ci)
Asparaginase, L- (escherichia coli)
Asparaginase from Escherichia coli,L-Asparagine Amidohydrolase
Sustanon Injection
LASPAR
1,2-Benzothiazol-3(2H)-one
CL059
Asparaginase (Owenism)
ASPARAGINASE
EC 3.5.1.1
L-ASPARAGINE AMIDOHYDROLASE
L-ASPARAGINASE
IUB: 3.5.4.4
colaspase
crasnitin
elspar
ASPARAGINASE FROM ESCHERICHIA COLI
Leucogen
L-ASNase
L-Asparagine Amidohydrolase
L-Asparaginase
Acrylaway L
Asparaginase 2
Asparaginase medac
Asparaginases
Colaspase
Crasnitin
Crasnitins
E.C. 3.5.1.1
Elspar
JZP 458

MDL Number

MFCD00130565

EC Number

232-765-3

Customs Code

3507909090

FAQ

What are the physical and chemical properties of L-Asparaginase (CAS: 9015-68-3)?

L-Asparaginase is a crystalline protein with a molecular weight of approximately 135 kDa. It is highly soluble in water and exhibits varying degrees of solubility in organic solvents. This enzyme is reactive towards asparagine, catalyzing its hydrolysis into aspartic acid and ammonia.

How is L-Asparaginase (CAS: 9015-68-3) typically synthesized?

L-Asparaginase is typically synthesized through microbial fermentation, utilizing E. coli or Streptomyces species as expression hosts. The production process involves genetic engineering to optimize enzyme yield and activity, with trypsin or other proteases often used as initial processing steps.

What industries use L-Asparaginase (CAS: 9015-68-3)?

L-Asparaginase is widely used in the pharmaceutical industry for the treatment of acute lymphoblastic leukemia. It is also employed in the food industry as a flavor enhancer and in the medical diagnostics sector for asparagine testing.

What precautions should be taken when handling L-Asparaginase (CAS: 9015-68-3)?

When handling L-Asparaginase, ensure the use of proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. In case of spill, neutralize with an appropriate agent and dispose of waste according to safety data sheet (SDS) guidelines.