L-Asparaginase(CAS: 9015-68-3)

L-Asparaginase is a crystalline protein with a molecular weight of approximately 135 kDa. It is highly soluble in water and exhibits varying degrees of solubility in organic solvents. This enzyme is reactive towards asparagine, catalyzing its hydrolysis into aspartic acid and ammonia.

L-Asparaginase is typically synthesized through microbial fermentation, utilizing E. coli or Streptomyces species as expression hosts. The production process involves genetic engineering to optimize enzyme yield and activity, with trypsin or other proteases often used as initial processing steps.

L-Asparaginase is widely used in the pharmaceutical industry for the treatment of acute lymphoblastic leukemia. It is also employed in the food industry as a flavor enhancer and in the medical diagnostics sector for asparagine testing.

When handling L-Asparaginase, ensure the use of proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. In case of spill, neutralize with an appropriate agent and dispose of waste according to safety data sheet (SDS) guidelines.