Heparin | CAS No. 9005-49-6

Heparin

Basic Information

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CAS Number

9005-49-6

Molecular Formula

C14H25N2O20S3

Molecular Weight

637.54 g/mol

EINECS

232-681-7

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

250 °C (decomp)

Specific Rotation

D20 +55°

SMILES

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CO[C@H]1O[C@H](COS(=O)(=O)O)[C@H]([C@@H]([C@H]1NS(=O)(=O)O)O)O[C@@H]1O[C@@H](C(=O)O)[C@H]([C@@H]([C@H]1OS(=O)(=O)O)O)OC.[N]

InChI

InChI=1S/C14H25NO20S3.N/c1-29-9-7(17)10(35-38(26,27)28)14(34-11(9)12(18)19)33-8-4(3-31-37(23,24)25)32-13(30-2)5(6(8)16)15-36(20,21)22;/h4-11,13-17H,3H2,1-2H3,(H,18,19)(H,20,21,22)(H,23,24,25)(H,26,27,28);/t4-,5-,6-,7+,8-,9+,10-,11-,13+,14-;/m1./s1

InChIKey

CKSLBFBQMMRQLA-LBUDAAJFSA-N

LogP

-5.422999999999995

Topological Polar Surface Area

348.01 Å²

Hydrogen Bond Donor/Acceptor

7 / 22

Safety Information

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Toxicity

LD50 oral in rat: 1950mg/kg

Synonyms & References

English

HEPARIN SODIUM (BOVINE)
HEPARIN SODIUM LMW
HEPARIN SODIUM, PORCINE
HEPARIN SODIUM SALT
HEPARIN PORCINE SODIUM SALT
LOW MOLECULAR WEIGHT HEPARIN SODIUM
PORCINE HEPARIN SODIUM
SODIUM HEPARIN
Heparin
BOVINE HEPARIN SODIUM
HEP, NA, BOVINE
HEP, NA, PORCINE
HEPARIN, SODIUM SALT, BOVINE
HEPARIN, SODIUM SALT, PORCINE
HEPARIN, SODIUM SALT, PORCINE INTESTINAL MUCOSA
ENOXAPARIN SODIUM
clarin
Depo heparin
Enoxaparine
HED heparin
liquaemin
LMWH-CA
pularin
thrombophob
6-[5-Acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid

EC Number

232-681-7

Customs Code

3001901000

FAQ

What are the physical and chemical properties of heparin (CAS: 9005-49-6)?

Heparin (CAS: 9005-49-6) is a naturally occurring anticoagulant with a highly charged, negatively polarized structure. It is a complex, heterogeneous mixture of highly sulfated glycosaminoglycans with a molecular weight ranging from 4,000 to 16,000 Da. Heparin is soluble in water and exhibits strong reactivity with proteins, particularly coagulation factors. It is commonly used in pharmaceutical and diagnostic applications due to its anticoagulant properties.

How is heparin (CAS: 9005-49-6) typically synthesized?

Heparin (CAS: 9005-49-6) is typically synthesized from porcine or bovine intestinal mucosa. The process involves extraction, purification, and depolymerization to obtain a suitable molecular weight range for clinical use. Enzymatic depolymerization using heparin lyase is a common method to achieve the desired properties. The yield and selectivity of the synthesis depend on the specific enzymatic conditions and purification steps.

What industries use heparin (CAS: 9005-49-6)?

Heparin (CAS: 9005-49-6) is widely used in the pharmaceutical industry for anticoagulant therapy. It is also utilized in the diagnostic industry for testing coagulation factors. Additionally, heparin-based materials are used in the biomedical industry for drug delivery systems and tissue engineering. In the research community, it is employed in cell culture and as a counterion in various biophysical assays.

What precautions should be taken when handling heparin (CAS: 9005-49-6)?

When handling heparin (CAS: 9005-49-6), it is important to follow safety guidelines to avoid adverse effects. Use personal protective equipment (PPE) such as gloves and goggles. Store heparin in a cool, dry place away from direct sunlight. In case of a spill, immediately clean up using appropriate materials and ensure proper disposal. Always review the Safety Data Sheet (SDS) for detailed handling and disposal instructions.