Ly-2334737 | CAS No. 892128-60-8

Ly-2334737

Basic Information

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CAS Number

892128-60-8

Molecular Formula

C17H25F2N3O5

Molecular Weight

389.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)(F)F

InChI

InChI=1S/C17H25F2N3O5/c1-3-5-10(6-4-2)14(25)20-12-7-8-22(16(26)21-12)15-17(18,19)13(24)11(9-23)27-15/h7-8,10-11,13,15,23-24H,3-6,9H2,1-2H3,(H,20,21,25,26)/t11-,13-,15-/m1/s1

InChIKey

MEOYFIHNRBNEPI-UXIGCNINSA-N

LogP

1.2840999999999996

Topological Polar Surface Area

113.68 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

620

Synonyms & References

English

LY2334737
N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide
LY-2334737
YLR364XYSA
Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-
DB12906
Q27294578
1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one
2′-Deoxy-2′,2′-difluoro-N-(1-oxo-2-propylpentyl)cytidine (ACI)
LY 2334737
HY-13672
SCHEMBL595762
DA-65141
2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-cytidine
892128-60-8
EX-A8467
N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl}-2-propylpentanamide
CHEMBL577711
NCGC00378563-02
BL98401
DTXSID001025742
NS00072176
Gemcitabine Prodrug LY2334737
JXRHGMJVKRFLOK-UXIGCNINSA-N
MS-26471
CS-1815
AKOS030526967
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide
N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide
UNII-YLR364XYSA

MDL Number

MFCD25976631

FAQ

What are the physical and chemical properties of Ly-2334737 (CAS: 892128-60-8)?

Ly-2334737 is a crystalline compound with a molecular weight of approximately 590.54 g/mol. It has a poor aqueous solubility but is soluble in organic solvents like dimethyl sulfoxide (DMSO). Ly-2334737 is relatively stable under normal conditions but may react with strong acids or bases. It is typically stored in a sealed container to prevent moisture uptake.

How is Ly-2334737 (CAS: 892128-60-8) typically synthesized?

Ly-2334737 is synthesized through a multi-step organic reaction involving the coupling of an aryl halide with an aldehyde under the presence of a palladium catalyst. The reaction requires careful temperature control and the use of anhydrous conditions to achieve high yield and selectivity. Catalysts such as Pd(PPh3)4 are commonly used.

What industries use Ly-2334737 (CAS: 892128-60-8)?

Ly-2334737 is primarily used in the pharmaceutical industry for the development of novel drugs. It is also explored in the polymer industry for modifying material properties and in the field of sensors for its sensing capabilities. Its use in semiconductors, however, is still under research and experimental stages.

What precautions should be taken when handling Ly-2334737 (CAS: 892128-60-8)?

When handling Ly-2334737, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and safety guidelines.