7-Fluoro-6-methoxyquinoline

Basic Information

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CAS Number

887769-91-7

Molecular Formula

C10H8FNO

Molecular Weight

177.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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COC1=C(C=C2C(=C1)C=CC=N2)F

InChI

InChI=1S/C10H8FNO/c1-13-10-5-7-3-2-4-12-9(7)6-8(10)11/h2-6H,1H3

InChIKey

SNKVCSRTSDJDKK-UHFFFAOYSA-N

LogP

2.3825000000000003

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

176

Synonyms & References

English

7-fluoro-6-methoxy-Quinoline
7-fluoro-6-methoxyquinoline
7-Fluoro-6-methoxyquinoline (ACI)
6-methoxy-7-fluoroquinoline
EN300-6764020
SCHEMBL622113
CS-0062006
AKOS024463749
AS-59203
DB-264085
SB68212
Z1258977719
MFCD19690247
887769-91-7

MDL Number

MFCD19690247

FAQ

What are the physical and chemical properties of 7-Fluoro-6-methoxyquinoline (CAS: 887769-91-7)?

7-Fluoro-6-methoxyquinoline is a yellow solid with a molecular weight of 218.14 g/mol. It has a high melting point of around 240°C and a low solubility in water (0.1 g/L at 25°C). It is slightly soluble in common organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions, making it useful in various synthetic transformations.

How is 7-Fluoro-6-methoxyquinoline (CAS: 887769-91-7) typically synthesized?

7-Fluoro-6-methoxyquinoline can be synthesized via a multistep process involving the protection of a hydroxyl group, fluorination, and subsequent deprotection. Common starting materials include 6-hydroxyquinoline. The reaction typically requires the use of Lewis acids or fluorinating agents like sulfuryl fluoride under anhydrous conditions. The overall yield is around 70-80%, depending on the purity of the starting materials and the conditions used.

What industries use 7-Fluoro-6-methoxyquinoline (CAS: 887769-91-7)?

7-Fluoro-6-methoxyquinoline is primarily used in the pharmaceutical industry for its potential as a bioisostere in drug molecules. It is also utilized in the dye-making sector, particularly in the production of certain dyes and pigments. Additionally, it finds applications in the polymer industry as a building block for specific polymers. Its electronic properties make it interesting for applications in sensors and semiconductors.

What precautions should be taken when handling 7-Fluoro-6-methoxyquinoline (CAS: 887769-91-7)?

When handling 7-Fluoro-6-methoxyquinoline, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.