2-(3,5-Difluorophenyl)pyrrolidine

Basic Information

View in Editor

CAS Number

886503-11-3

Molecular Formula

C10H11F2N

Molecular Weight

183.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

221℃

Density

1.164

Flash Point

88℃

SMILES

View in Editor

C1CC(NC1)C2=CC(=CC(=C2)F)F

InChI

InChI=1S/C10H11F2N/c11-8-4-7(5-9(12)6-8)10-2-1-3-13-10/h4-6,10,13H,1-3H2

InChIKey

INAOTHVFVJELEL-UHFFFAOYSA-N

LogP

2.3892999999999995

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

164

Synonyms & References

English

CS-0173244
886503-11-3
A26455
FT-0761122
AS-79278
EN300-1069896
AKOS000155332
DTXSID50602679
2-(3,5-difluorophenyl)pyrrolidine
N12968
SB44284
MFCD06740446
SCHEMBL18704814
Pyrrolidine, 2-(3,5-difluorophenyl)-
2-(3,5-DIFLUORO-PHENYL)-PYRROLIDINE HYDROCHLORIDE
B-1527
2-(3,5-Difluorophenyl)pyrrolidine (ACI)

MDL Number

MFCD06740446

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-(3,5-Difluorophenyl)pyrrolidine (CAS: 886503-11-3)?

2-(3,5-Difluorophenyl)pyrrolidine is a colorless liquid at room temperature. Its molecular weight is approximately 186.07 g/mol, and it has a slight solubility in water. It is moderately reactive with strong oxidizing agents. The compound exhibits good stability under normal storage conditions but should be handled with care to avoid exposure to heat and light.

How is 2-(3,5-Difluorophenyl)pyrrolidine (CAS: 886503-11-3) typically synthesized?

2-(3,5-Difluorophenyl)pyrrolidine is typically synthesized through a multistep process involving the protection, substitution, and deprotection of a pyrrolidine ring. Common starting materials include fluoroaniline, and the reaction often requires a Lewis acid catalyst for the key substitution step. The yield and selectivity can be enhanced with appropriate choice of reagents and conditions.

What industries use 2-(3,5-Difluorophenyl)pyrrolidine (CAS: 886503-11-3)?

2-(3,5-Difluorophenyl)pyrrolidine is used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also utilized in the polymer industry for the modification of polymer chains, and in the sensor and semiconductor industries for tailored material properties. Its unique chemical structure makes it a valuable reagent in a variety of applications.

What precautions should be taken when handling 2-(3,5-Difluorophenyl)pyrrolidine (CAS: 886503-11-3)?

When handling 2-(3,5-Difluorophenyl)pyrrolidine, it is essential to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably a fume hood, to avoid inhalation or skin contact. In case of spill, immediately clean up with appropriate absorbent material and follow proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency instructions.