2-(3,5-Difluorophenyl)pyrrolidine(CAS: 886503-11-3)

2-(3,5-Difluorophenyl)pyrrolidine is a colorless liquid at room temperature. Its molecular weight is approximately 186.07 g/mol, and it has a slight solubility in water. It is moderately reactive with strong oxidizing agents. The compound exhibits good stability under normal storage conditions but should be handled with care to avoid exposure to heat and light.

2-(3,5-Difluorophenyl)pyrrolidine is typically synthesized through a multistep process involving the protection, substitution, and deprotection of a pyrrolidine ring. Common starting materials include fluoroaniline, and the reaction often requires a Lewis acid catalyst for the key substitution step. The yield and selectivity can be enhanced with appropriate choice of reagents and conditions.

2-(3,5-Difluorophenyl)pyrrolidine is used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also utilized in the polymer industry for the modification of polymer chains, and in the sensor and semiconductor industries for tailored material properties. Its unique chemical structure makes it a valuable reagent in a variety of applications.

When handling 2-(3,5-Difluorophenyl)pyrrolidine, it is essential to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably a fume hood, to avoid inhalation or skin contact. In case of spill, immediately clean up with appropriate absorbent material and follow proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency instructions.