Filanesib | CAS No. 885060-09-3

Filanesib

Basic Information

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CAS Number

885060-09-3

Molecular Formula

C20H22F2N4O2S

Molecular Weight

420.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC

InChI

InChI=1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1

InChIKey

LLXISKGBWFTGEI-FQEVSTJZSA-N

LogP

3.880300000000002

Topological Polar Surface Area

71.16000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

605

Synonyms & References

English

(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide
ARRY-520
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
ARRY 520 trifluoroacetate
ARRY520
Filanesib
(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (ACI)
(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
ARRY 520
CHEMBL2347655
BRD-K37379014-001-02-0
BCP07442
SB19209
EX-A678
Q15634095
CS-0867
FILANESIB [WHO-DD]
UNII-8A49OSO368
NCGC00381751-04
FILANESIB [USAN]
1,3,4-Thiadiazole-3(2H)-carboxamide,2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)-
SCHEMBL368043
NCGC00381751-02
HMS3750A15
885060-09-3
MS-27382
8A49OSO368
Filanesib [USAN:INN]
Filanesib(ARRY-520)
DTXSID50237086
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide

MDL Number

MFCD18633235

FAQ

What are the physical and chemical properties of Filanesib (CAS: 885060-09-3)?

Filanesib is a yellow crystalline solid with a molecular weight of approximately 739.75 g/mol. It has a solubility of about 0.012 mg/mL in water and is poorly soluble in common organic solvents. Chemically, Filanesib is stable under normal conditions but may react with strong acids or bases. It is a potent inhibitor of the p70S6 kinase, making it a critical drug candidate in oncology research.

How is Filanesib (CAS: 885060-09-3) typically synthesized?

Filanesib is synthesized through a multi-step process involving condensation reactions, ring formation, and functional group transformations. Commonly, it uses catalysts such as palladium or titanium complexes. The synthesis yields a selective and potent inhibitor with a high purity, ensuring its efficacy in clinical trials and research.

What industries use Filanesib (CAS: 885060-09-3)?

Filanesib is primarily used in the pharmaceutical industry for its potential in oncology. It is also being explored in research for its effects on cellular signaling pathways. While its industrial applications are currently limited, it shows promise in developing new treatments for various cancers and other diseases.

What precautions should be taken when handling Filanesib (CAS: 885060-09-3)?

When handling Filanesib, wear appropriate personal protective equipment (PPE) such as gloves and lab coats. Work in a well-ventilated area or under a fume hood to minimize inhalation risks. Store the compound in a cool, dry place away from direct sunlight. In case of a spill, clean up immediately and refer to the Safety Data Sheet (SDS) for specific guidance on disposal guidelines.